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Semin Thromb Hemost 2008; 34(4): 373-379
DOI: 10.1055/s-0028-1085480
© Thieme Medical Publishers

Laboratory Testing for Lupus Anticoagulants: Diagnostic Criteria and Use of Screening, Mixing, and Confirmatory Studies

Armando Tripodi1
  • 1Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
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Publication History

Publication Date:
23 September 2008 (online)

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ABSTRACT

The presence of lupus anticoagulants (LA) in plasma is a strong risk factor for thromboembolism and fetal loss. Because of this, demand for testing for LA is increasing, but the performance of clinical laboratories in terms of its detection is still a matter of concern. This is due in part to the lack of specific tests but also to the lack of standardization and application of the diagnostic criteria. The aim of this article is to review the diagnostic criteria and the many issues that may affect test results.

KEYWORDS

Thrombophilia testing - antiphospholipid syndrome - thrombosis - fetal loss

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Dr. Armando Tripodi

Via Pace 9, 20122 Milan

Italy

Email: armando.tripodi@unimi.it