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Synthesis 2011(4): 517-538
DOI: 10.1055/s-0030-1258328
DOI: 10.1055/s-0030-1258328
REVIEW
© Georg Thieme Verlag
Stuttgart ˙ New York
α-Functionalization of Carbonyl Compounds Using Hypervalent Iodine Reagents
Further Information
Received
19 September 2010
Publication Date:
15 November 2010 (online)
Publication History
Publication Date:
15 November 2010 (online)
Abstract
α-Functionalized carbonyl compounds are versatile intermediates in organic synthesis. A broad range of both carbon and heteroatom substituents can be introduced into the α-position of carbonyl compounds using hypervalent iodine reagents. Herein we summarize the use of these environmentally benign reagents with particular emphasis on catalytic and asymmetric methodology developed over the past decade.
1 Introduction
2 Oxygenation
3 Halogenation
4 Trifluoromethylation
5 Arylation
6 Alkynylation and Alkenylation
7 Homocoupling
8 Functionalization of α,β-Unsaturated Carbonyl Compounds
9 Miscellaneous
10 Summary
Key words
catalysis - asymmetric synthesis - oxidation - hypervalent iodine - C-C bond formation
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