Mild Oxidation of Benzylic Amines into Aldehydes Using an Oxidative Polonovski-Like Process

Abstract

A chemoselective and environmentally benign oxidation of benzylic amines into aldehydes mediated by a hypervalent iodine reagent has been developed. This mild oxidative version of the ­Polonovski process may be selectively carried out in the presence of several functionalities including a free alcohol and provides new synthetic opportunities as a masked aldehyde segment.

Key words

hypervalent iodine - oxidation - amines - Polonovski - ­aromatic aldehydes

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