Synlett 2012; 23(9): 1384-1388
DOI: 10.1055/s-0031-1291015
letter
© Georg Thieme Verlag Stuttgart · New York

Microwave-Assisted Regiospecific Synthesis of Pseudohalohydrin Esters

Mirna El Khatib
a   Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA, Email: katritzky@chem.ufl.edu
,
Mohamed Elagawany
a   Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA, Email: katritzky@chem.ufl.edu
b   Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt
c   Department of Organic Chemistry, College of Pharmacy, Misr University for Science and Technology, Al-Motamayez District, P.O. Box 77, 6th of October City, Egypt
,
Ekaterina Todadze
a   Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA, Email: katritzky@chem.ufl.edu
,
Levan Khelashvili
a   Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA, Email: katritzky@chem.ufl.edu
,
Said A. El-Feky
b   Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt
,
Alan R. Katritzky*
a   Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA, Email: katritzky@chem.ufl.edu
d   Department of Chemistry, King Abdulaziz University, Jeddah 21589, Saudi Arabia
› Author Affiliations
Further Information

Publication History

Received: 06 January 2012

Accepted after revision: 22 February 2012

Publication Date:
14 May 2012 (online)


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Abstract

N-Acylbenzotriazoles react regiospecifically with epoxides under palladium catalysis to give novel β-(benzotriazol-1-yl)ethyl esters (52–87%) constituting halohydrin ester surrogates.

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