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Synlett 2012; 23(18): 2603-2608
DOI: 10.1055/s-0032-1317329
letter
© Georg Thieme Verlag Stuttgart · New York

Transition-Metal-Catalyzed Arylation of 1-Deazapurines via C–H Bond Activation

Viktor O. Iaroshenko*
a   Institut für Chemie, Universität Rostock, Albert-Einstein-Str. 3a, 18059 Rostock, Germany   Fax: +49(381)49864112   Email: viktor.iaroshenko@uni-rostock.de   Email: iva108@googlemail.com
b   National Taras Shevchenko University, 62 Volodymyrska st., Kyiv-33, 01033, Ukraine
,
Iftikhar Ali
a   Institut für Chemie, Universität Rostock, Albert-Einstein-Str. 3a, 18059 Rostock, Germany   Fax: +49(381)49864112   Email: viktor.iaroshenko@uni-rostock.de   Email: iva108@googlemail.com
,
Satenik Mkrtchyan
a   Institut für Chemie, Universität Rostock, Albert-Einstein-Str. 3a, 18059 Rostock, Germany   Fax: +49(381)49864112   Email: viktor.iaroshenko@uni-rostock.de   Email: iva108@googlemail.com
,
Volodymyr Semeniuchenko
b   National Taras Shevchenko University, 62 Volodymyrska st., Kyiv-33, 01033, Ukraine
,
Dmytro Ostrovskyi
a   Institut für Chemie, Universität Rostock, Albert-Einstein-Str. 3a, 18059 Rostock, Germany   Fax: +49(381)49864112   Email: viktor.iaroshenko@uni-rostock.de   Email: iva108@googlemail.com
,
Peter Langer
a   Institut für Chemie, Universität Rostock, Albert-Einstein-Str. 3a, 18059 Rostock, Germany   Fax: +49(381)49864112   Email: viktor.iaroshenko@uni-rostock.de   Email: iva108@googlemail.com
c   Leibniz-Institut für Katalyse e. V. an der Universität Rostock, Albert-Einstein-Str. 29a, 18059 Rostock, Germany
› Author Affiliations
Further Information

Publication History

Received: 02 August 2012

Accepted after revision: 06 September 2012

Publication Date:
01 October 2012 (online)

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Abstract

Transition-metal-catalyzed arylation of imidazo[4,5-b]pyridines (known as 1-deazapurines) is reported. 1-Deazapurines were synthesized from 5-aminoimidazoles, generated in situ by the reaction of methyl N-(cyanomethyl)formimidate with primary amines.

Key words

catalysis - nickel - C–H activation - arylation - 1-deazapurine - imidazole

Supporting Information

    for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
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