Development and Challenges in the Copper-Catalyzed Trifluoromethylation of Alkenes

Xiaowu Liu; Xiaoxing Wu

doi:10.1055/s-0033-1339684

Synlett, Inhaltsverzeichnis

Synlett 2013; 24(15): 1882-1886
DOI: 10.1055/s-0033-1339684

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Development and Challenges in the Copper-Catalyzed Trifluoromethylation of Alkenes

Xiaowu Liu

Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, P. R. of China Fax: +86(20)32093615 eMail: wu_xiaoxing@gibh.ac.cn

,

Xiaoxing Wu*

Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, P. R. of China Fax: +86(20)32093615 eMail: wu_xiaoxing@gibh.ac.cn

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Abstract

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Abstract

The recent trifluoromethylation of unactivated alkenes and related compounds provides a new and straightforward method to mainly form C_sp3–CF₃ bonds. However, several mechanisms have been proposed for the system of copper catalysts and electrophilic trifluoromethylating reagents. This paper differentiated the radical mechanism from others experimentally and computationally by investigating the chemoselectivity in the rearrangement of unsymmetrical α,α-diaryl allylic alcohols. Moreover, it outlines some future directions in this field.

Key words

trifluoromethylation - copper-catalyzed - migration - radical - allylic alcohol

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Referenzen

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