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Synlett 2013; 24(19): 2465-2471
DOI: 10.1055/s-0033-1339875
DOI: 10.1055/s-0033-1339875
synpacts
Search for Ideal P-Chiral Phosphorus Ligands for Practical Asymmetric Hydrogenation and Asymmetric Suzuki–Miyaura Coupling
Further Information
Publication History
Received: 12 August 2012
Accepted after revision: 03 September 2013
Publication Date:
23 September 2013 (online)
Abstract
The synthesis of P-chiral phosphorus ligands with novel structures is important for the development of efficient asymmetric catalytic transformations. Here, we describe the development of P-chiral phosphorus ligands such as BIBOP, WingPhos, BI-DIME, and 8 in our laboratory. Conformational rigidity, high tunability of electronic and steric properties, and convenient physical properties are the main features of our ligand design. Progress in developing practical asymmetric hydrogenation and asymmetric cross-coupling reactions are discussed.