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Synlett 2014; 25(5): 724-728
DOI: 10.1055/s-0033-1340673
letter
© Georg Thieme Verlag Stuttgart · New York

Copper Hydride Catalyzed Reductive Aldol Addition/Lactonization Domino Reactions of α,β-Unsaturated Diesters

Zengchang Li
a   College of Environmental and Chemical Engineering, Dalian University, Dalian 116622, P. R. of China   Fax: +86(411)87402449   Email: znli@dl.cn
,
Zhenlei Zhang
a   College of Environmental and Chemical Engineering, Dalian University, Dalian 116622, P. R. of China   Fax: +86(411)87402449   Email: znli@dl.cn
,
Lu Yuan
a   College of Environmental and Chemical Engineering, Dalian University, Dalian 116622, P. R. of China   Fax: +86(411)87402449   Email: znli@dl.cn
,
Lan Jiang
a   College of Environmental and Chemical Engineering, Dalian University, Dalian 116622, P. R. of China   Fax: +86(411)87402449   Email: znli@dl.cn
,
Zhansheng Li
b   College of Chemical Engineering, Dalian University of Technology, Dalian 116023, P. R. of China
,
Zhengning Li*
a   College of Environmental and Chemical Engineering, Dalian University, Dalian 116622, P. R. of China   Fax: +86(411)87402449   Email: znli@dl.cn
› Author Affiliations
Further Information

Publication History

Received: 25 November 2013

Accepted after revision: 05 January 2014

Publication Date:
27 January 2014 (online)

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Abstract

The first copper-catalyzed reductive aldol addition/lactonization domino reactions of α,β-unsaturated dicarboxylate esters with ketones were achieved in high yields. The method, which involves easily available reagents, a flexible combination of reactants, and mild conditions, provides a simple route to functionalized lactones bearing an ester group.

Key words

reductions - aldol reactions - lactones - domino reactions - copper - catalysis
 

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