Synlett 2014; 25(09): 1283-1286
DOI: 10.1055/s-0033-1341107
letter
© Georg Thieme Verlag Stuttgart · New York

Synthesis of 7-epi-Goniodiol by Proline-Catalyzed Diastereoselective Direct Aldol Reaction

Bacchu Veena*
D-211, Discovery Laboratory, Organic & Biomolecular Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India   Fax: +91(40)27160387   Email: veenabachhu@gmail.com
,
Gangavaram V. M. Sharma
D-211, Discovery Laboratory, Organic & Biomolecular Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India   Fax: +91(40)27160387   Email: veenabachhu@gmail.com
› Author Affiliations
Further Information

Publication History

Received: 04 January 2014

Accepted after revision: 13 March 2014

Publication Date:
28 April 2014 (online)


Abstract

A simple organocatalytic approach was developed for the total synthesis of 7-epi-goniodiol. The strategy involves l-proline-catalyzed diastereoselective direct aldol reaction and Baeyer–Villiger oxidation as key steps for the construction of chiral lactone.

Supporting Information