Advances in Transition-Metal-Catalyzed Direct sp³-Carbon–Hydrogen Bond Functionalization

Abstract

Transition-metal-catalyzed direct carbon–hydrogen bond functionalization has made significant advances in the field of carbon–hydrogen bond activation over the past decades. This methodology has the potential to be used in many different areas of chemistry; for example, it can provide an opportunity for the synthesis of various kinds of complex compounds. This account mainly focuses on recent advances in transition-metal-catalyzed direct sp³-carbon–hydrogen bond functionalization to form carbon–carbon bonds.

1 Introduction

2 Carbon–Carbon Bond Formation via Direct sp³-Carbon–Hydrogen Bond Functionalization

2.1 Coupling of sp³-Carbon–Hydrogen and sp-Carbon–Hydrogen Bonds

2.2 Coupling of sp³-Carbon–Hydrogen and sp²-Carbon–Hydrogen Bonds

2.3 Coupling of sp³-Carbon–Hydrogen and sp³-Carbon–Hydrogen Bonds

2.4 Coupling of sp³-Carbon–Hydrogen and C–X Bonds

3 Conclusion

Key words

transition metals - catalysis - carbon–carbon bond formations - cross-dehydrogenative coupling - direct bond functionalizations

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