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Synlett 2017; 28(09): 1051-1056
DOI: 10.1055/s-0036-1588415
DOI: 10.1055/s-0036-1588415
letter
Tandem Oxidative Phenol Dearomatization/Formal [3+2] Annulation Protocol En Route to Highly Functionalized Benzothiophenes
Further Information
Publication History
Received: 26 October 2016
Accepted after revision: 17 January 2017
Publication Date:
09 February 2017 (online)
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Abstract
A new strategy for the synthesis of benzothiophenes through formal [3+2] annulation of sulfanylacetaldehyde and cyclohexa-2,4-dien-1-one monoketals has been developed. This approach relies on the ease of aromatization of tetrahydrobenzothiophenone derivatives prepared by the aforementioned protocol. Given the ready accessibility of various substituted cyclohexa-2,4-dien-1-one monoketals, a range of benzothiophene derivatives became available.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0036-1588415.
- Supporting Information