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Synthesis 2018; 50(02): 193-210
DOI: 10.1055/s-0036-1589520
DOI: 10.1055/s-0036-1589520
review
Recent Advances in Direct C–H Functionalization of Pyrimidines
The research was financially supported by the Russian Science Foundation (Project No. 15-13-00077).Further Information
Publication History
Received: 24 August 2017
Accepted after revision: 15 September 2017
Publication Date:
14 December 2017 (online)
Abstract
Data spanning the period 2000–2017 on the direct C–H functionalization of pyrimidines are collected and discussed in this review. This demonstrates the surge of interest and creativity that this field of chemistry has experienced during the last two decades. Plausible applications of highly functionalized pyrimidines are also discussed.
1 Introduction
2 Transition-Metal-Catalyzed C–H Functionalization of Pyrimidine Derivatives
3 Transition-Metal-Free Direct C–H Functionalization of Pyrimidine Derivatives
4 Deprotonative Metalation of Pyrimidine Derivatives
5 Conclusions
-
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