Synlett 2019; 30(01): 21-29
DOI: 10.1055/s-0037-1610263
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© Georg Thieme Verlag Stuttgart · New York

Recent Applications of α-Carbonyl Sulfoxonium Ylides in Rhodium- and Iridium-Catalyzed C–H Functionalizations

Xiaopeng Wu
,
Song Sun
,
Jin-Tao Yu
,
Jiang Cheng*
School of Petrochemical Engineering, and Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, Changzhou University, Changzhou 213164, P. R. of China   Email: jiangcheng@cczu.edu.cn
› Author Affiliations

We thank the National Natural Science Foundation of China (No. 21572025), ‘Innovation & Entrepreneurship Talents’ Introduction Plan of Jiangsu Province, Natural Science Foundation of Jiangsu Province (BK20171193), the Key University Science Research Project of Jiangsu Province (15KJA150001), Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology (BM2012110), and the Advanced Catalysis and Green Manufacturing Collaborative Innovation Center for their financial support. S.S. thanks the National Natural Science Foundation of China (No. 21602019) and the Young Natural Science Foundation of Jiangsu Province (BK20150263) for financial support.
Further Information

Publication History

Received: 10 July 2018

Accepted after revision: 06 August 2018

Publication Date:
05 September 2018 (online)


Abstract

Sulfoxonium ylides are a special type of sulfur ylides that serve as new C1 or C2 synthons recently developed for use in C–H functionalization to access acylmethylated or cyclized compounds through the formation of metal carbene species. Many excellent works have reported the syntheses of various useful skeletons from these versatile synthons. These developments have not previously been completely investigated or reviewed. In this review, we summarize recent advances in the use of α-carbonyl sulfoxonium ylides in C–H functionalizations, including ortho-C–H acylmethylation reactions and ortho-C–H activation/cyclization reactions.

Table of Contents

1 Introduction

2 Ortho-C–H Acylmethylation Reactions

3 Ortho-C–H Activation/Cyclization Reactions

3.1 Ortho-C–H Activation/Cyclization of Anilines and Enamines

3.2 Ortho-C–H Activation/Cyclization of Azobenzenes

3.3 Ortho-C–H Activation/Cyclization of N-Methoxybenzamide

3.4 Ortho-C–H Activation/Cyclization of Imines

3.5 Ortho-C–H Activation/Cyclization of N-Azoloimines

3.6 Ortho-C–H Activation/Cyclization of Benzoylacetonitriles

3.7 Ortho-C–H Activation/Cyclization of Benzoyl Sulfoxonium Ylides

4 Conclusion