Transition-Metal-Free Synthesis of Thiosulfonates through Radical Coupling Reaction

^◊ These authors contributed equally to this work

Abstract

An efficient and practical transition-metal-free radical ­coupling reaction of sulfonyl hydrazides mediated by NIS/K₂S₂O₈ has been developed to afford a variety of biological activity thiosulfonates in moderate to excellent yields. Compared to a known approach for the synthesis of thiosulfonates from sulfonyl hydrazides, this strategy features high yields, mild reaction conditions, and broad substrate scope. The mechanistic studies revealed that the procedure undergoes via a radical cross-coupling process for the construction of S–S bonds.

Keywords

transition-metal-free - radical coupling reaction - S–S bonds - thiosulfonates

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