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Synthesis 2019; 51(22): 4113-4136
DOI: 10.1055/s-0037-1611910
DOI: 10.1055/s-0037-1611910
review
Recent Developments in Direct C–H Functionalization of Quinoxalin-2(1H)-ones via Radical Addition Processes
M. thanks the Council of Scientific & Industrial Research (CSIR), New Delhi, India, for a research fellowship. S.S. thanks the Scientific and Engineering Research Board (SERB), New Delhi, India (ECR/2018/000413) for financial support and the University Grants Commission (UGC), New Delhi, for a UGC-FRP faculty award [F.4-5(3-FRP)/2017(BSR)].Further Information
Publication History
Received: 15 June 2019
Accepted after revision: 22 July 2019
Publication Date:
24 September 2019 (online)
Dedicated to Professor Vinod K. Singh, IIT Kanpur on the occasion of his 60th birthday
Abstract
This review article covers the recent developments in direct C–H functionalization of quinoxalin-2(1H)-one derivatives via radical additions at the C3 position. Reaction types have been categorized depending on the kind of radical used, with representative examples and insightful mechanistic details provided.
1 Introduction
2 Reactions with Alkyl Radicals
3 Reactions with Acyl Radicals
4 Reactions with Aryl Radicals
5 Reactions with Perfluoroalkyl Radicals
6 Reactions with Alkoxycarbonyl Radicals
7 Reactions with Nitrogen Radicals
8 Reactions with Oxygen Radicals
9 Reactions with Phosphorus Radicals
10 Conclusion
-
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