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Thromb Haemost 1998; 79(01): 99-103
DOI: 10.1055/s-0037-1614228
Review Article
Schattauer GmbH

Relationship between Thyroid Hormones and Plasma D-dimer Levels

Rita Chadarevian
From Service d’Endocrinologie-Métabolisme, Hôpital Pitié Salpétrière, Paris, France
,
Eric Bruckert
From Service d’Endocrinologie-Métabolisme, Hôpital Pitié Salpétrière, Paris, France
,
Annick Ankri
From Service d’Endocrinologie-Métabolisme, Hôpital Pitié Salpétrière, Paris, France
,
Isabel Beucler
From Service d’Endocrinologie-Métabolisme, Hôpital Pitié Salpétrière, Paris, France
,
Philippe Giral
From Service d’Endocrinologie-Métabolisme, Hôpital Pitié Salpétrière, Paris, France
,
Gérard Turpin
From Service d’Endocrinologie-Métabolisme, Hôpital Pitié Salpétrière, Paris, France
› Author Affiliations
Further Information

Publication History

Received 07 October 1996

Accepted after resubmission 14 August 1997

Publication Date:
08 December 2017 (online)

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Summary

High serum levels of cholesterol and triglycerides are risk factors for coronary heart disease and are strongly related to several haemostatic parameters. Thyroid disorders are a frequent feature in hyperlipidemic patients and are also associated with a variety of haemostatic abnormalities. Therefore, we analysed the relationships between free T4 (fT4) levels and Factor VII and VIII activities (FVIIc and FVIIIc), D-Dimers (DDI) and Plasminogen Activator Inhibitor type 1 (PAI-1), in a group of 472 healthy patients referred for hyperlipidemia.

Fourty patients were found to have primary hypothyroidism. A negative correlation was found in the whole study population between fT4 and DDI (p = 0.0001, r = –0.21) and the same results were found after exclusion of the patients with fT4 below the normal range (p = 0.0007, r = –0.17). In a multivariate regression analysis, the relationship between DDI and fT4 was independent of age, Body Mass Index (BMI), gender and total cholesterol. Less impressive correlation coefficients were found with FVIIc (r = –0.10), FVIIIc (r = –0.09) and PAI-1 (r = –0.09).

These results suggest that fT4 may play a physiological role in the regulation of the haemostatic equilibrium in hyperlipidemic patients and that low levels of fT4 are associated with a hypercoagulable state.

 

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