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Thromb Haemost 1999; 81(01): 146-150
DOI: 10.1055/s-0037-1614432
Review Article
Schattauer GmbH

Human Atheromatous Plaque Extracts Induce Tissue Factor Activity (TFa) in Monocytes and also Express Constitutive TFa

Thomas W. Muhlfelder
1   From the Bronx VA Medical Center and The Mount Sinai School of Medicine, New York, USA
,
Victoria Teodorescu
1   From the Bronx VA Medical Center and The Mount Sinai School of Medicine, New York, USA
,
Jacob Rand
1   From the Bronx VA Medical Center and The Mount Sinai School of Medicine, New York, USA
,
Alan Rosman
1   From the Bronx VA Medical Center and The Mount Sinai School of Medicine, New York, USA
,
Julian Niemetz
1   From the Bronx VA Medical Center and The Mount Sinai School of Medicine, New York, USA
› Author Affiliations
Further Information

Publication History

Received16 June 1997

Accepted after resubmission14 September 1998

Publication Date:
08 December 2017 (online)

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Summary

Tissue factor activity (TFa) is a major activator of the coagulation cascade and may play a role in atheroma-induced thrombosis. Mono-cyte-macrophages (MO-MF) generate considerable quantities of TFa when stimulated by a variety of inducers. To test the hypothesis that MO could be induced by atheromatous plaque to generate TFa, plaque extracts obtained from patients with obstructive atheromatous disease were used. These extracts were also assayed for constitutive TFa. The constitutive activity was variable from extract to extract but could be very high, up to 250 U TFa. The TFa induced in MO could be also very high, up to 200 U (i.e. 1/5 of the TFa of full strength rabbit brain thromboplastin). These findings point to a major role for MO-MF TFa in the induction or thrombosis by atheromatous plaque.

 

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