Evolution of Antibodies Anti-PF4/heparin in a Patient with a History of Heparin-induced Thrombocytopenia Reexposed to Heparin

Thromb Haemost 1994; 72(05): 783-784
DOI: 10.1055/s-0038-1648959

Letter to the Editor

Schattauer GmbH Stuttgart

Y Cadroy

¹Laboratoire d’Hématologie, Hôpital Purpan, Toulouse, France

,

J Amiral

²Serbio Laboratories, Genevilliers, France

,

H Raynaud

³Clinique Pasteur, Toulouse, France

,

P Brunel

³Clinique Pasteur, Toulouse, France

,

A Mazaleyrat

³Clinique Pasteur, Toulouse, France

,

M Sauer

³Clinique Pasteur, Toulouse, France

,

P Sié

¹Laboratoire d’Hématologie, Hôpital Purpan, Toulouse, France

References
1 Greinacher A, Potzsch B, Amiral J, Dummel V, Eichner A, Mueller-Eckhardt C. Heparin-associated thrombocytopenia: isolation of the antibody and characterization of a multimolecular PF4-Heparin complex as the major antigen. Thromb Haemost 1994; 71: 247-251
2 Amiral J, Bridey F, Dreyfus M, Vissac AM, Freyssinaud E, Wolf M, Meyer D. Platelet factor 4 complexed to heparin is the target for antibodies generated in heparin-induced thrombocytopenia. Thromb Haemost 1992; 68: 95-96
3 Magnani HN. Heparin-induced thrombocytopenia (HIT): an overview of 230 patients treated with Orgaran (Org 10172). Thromb Haemost 1993; 70: 554-561