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Thromb Haemost 1996; 76(05): 738-742
DOI: 10.1055/s-0038-1650653
Original Article
Schattauer GmbH Stuttgart

Interleukin-6 Stimulates Coagulation, not Fibrinolysis, in Humans

Jacqueline M L Stouthard
1   The Department of Internal Medicine, Department of Endocrinology and Metabolism, all from the Academic Medical Centre, University of Amsterdam, The Netherlands
5   Metabolic Research Group, Department of Endocrinology and Metabolism, all from the Academic Medical Centre, University of Amsterdam, The Netherlands
,
Marcel Levi
1   The Department of Internal Medicine, Department of Endocrinology and Metabolism, all from the Academic Medical Centre, University of Amsterdam, The Netherlands
2   Centre for Haemostasis, Thrombosis, Atherosclerosis, and Inflammation Research, Department of Endocrinology and Metabolism, all from the Academic Medical Centre, University of Amsterdam, The Netherlands
,
C Erik Hack
3   Department of Autoimmune Diseases, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands
,
Cees H N Veenhof
4   Department of Medical Oncology , Department of Endocrinology and Metabolism, all from the Academic Medical Centre, University of Amsterdam, The Netherlands
,
Hans A Romijn
5   Metabolic Research Group, Department of Endocrinology and Metabolism, all from the Academic Medical Centre, University of Amsterdam, The Netherlands
,
Hans P Sauerwein
5   Metabolic Research Group, Department of Endocrinology and Metabolism, all from the Academic Medical Centre, University of Amsterdam, The Netherlands
,
Tom van der Poll
1   The Department of Internal Medicine, Department of Endocrinology and Metabolism, all from the Academic Medical Centre, University of Amsterdam, The Netherlands
› Author Affiliations
Further Information

Publication History

Received 08 February 1996

Accepted after resubmission 19 June 1996

Publication Date:
11 July 2018 (online)

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Summary

The role of IL-6 as a mediator of haemostatic changes during severe inflammation is controversial. To assess the effect of IL-6 on haemostasis we conducted a controlled cross-over study in eight patients with metastatic renal cell cancer. In all subjects coagulation and fibrinolysis were monitored during and after a 4-h infusion of either 150 μg recombinant human (rh) IL-6, or during infusion of saline (control study). Mean maximum IL-6 concentrations were 1418.0 ± 755.8 pg/ml. Compared to the control study, rhIL-6 induced activation of coagulation as reflected by a 190 ± 55% increase in the plasma levels of thrombin-antithrombin III complexes (p <0.001) and by a 24 ± 11% increase in the plasma levels of in the prothrombin activation fragment F1 + 2 (p <0.001). In contrast, fibrinolysis was not affected. We conclude that in severe inflammation IL-6 may contribute to the activation of coagulation, whereas other factors mediate changes in fibrinolysis.

 

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