CC BY-ND-NC 4.0 · SynOpen 2019; 03(03): 77-90
DOI: 10.1055/s-0039-1690686
short review
Copyright with the author(s) (2019) The author(s)

Catalytic Enantioselective Approaches to the oxa-Pictet–Spengler Cyclization and Other 3,6-Dihydropyran-Forming Reactions

Zhengbo Zhu
a   Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611, USA   eMail: seidel@chem.ufl.edu
,
Alafate Adili
a   Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611, USA   eMail: seidel@chem.ufl.edu
,
b   Department of Chemistry, University of California–Berkeley; Materials Sciences Division, Lawrence Berkeley National Laboratory; Kavli Energy NanoSciences Institute at Berkeley; Berkeley Global Science Institute, Berkeley, California 94720, USA
,
Daniel Seidel
a   Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611, USA   eMail: seidel@chem.ufl.edu
› Institutsangaben
This material is based upon work supported by the National Science Foundation under grant CHE–1856613.
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Publikationsverlauf

Received: 24. August 2019

Accepted after revision: 04. September 2019

Publikationsdatum:
25. September 2019 (online)


Abstract

This Short Review provides an analysis of the state-of-the-art in catalytic enantioselective oxa-Pictet–Spengler cyclizations. Also discussed are other catalytic reactions providing access to enantio­enriched isochromans and tetrahydropyrano[3,4-b]indoles. Context is provided and remaining challenges are highlighted.