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Synlett 1991; 1991(9): 643-644
DOI: 10.1055/s-1991-20825
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Direct Trifluoromethylation of α-Keto Esters to β, β, β-Trifluorolactic Acid Derivatives Using Trifluoromethyltrimethylsilane

Pichika Ramaiah* , G. K. Surya Prakash
  • *Donald P. and Katherine B. Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, Los Angeles, California 90089-1661, USA
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Publication Date:
07 March 2002 (online)

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Several β, β, β-trifluorolactic acid derivatives [2-hydroxy-2-(trifluoromethyl)alkanoic esters] were prepared by the fluoride induced direct trifluoromethylation of α-keto esters using trifluoromethyltrimethylsilane.