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Synlett 1992; 1992(8): 673-676
DOI: 10.1055/s-1992-21454
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Metal Salt-Promoted Alcoholysis of 1,2-Epoxides

Marco Chini* , Paolo Crotti, Cristina Gardelli, Franco Macchia
  • *Dipartimento di Chimica Bioorganica, Università di Pisa, Via Bonanno 33, I-56126 Pisa, Italy
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Publication History

Publication Date:
08 March 2002 (online)

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A simple, efficient, stereoselective, and regioselective method for the synthesis of ß-alkoxy alcohols by the direct opening of 1,2-epoxides with alcohols (primary, secondary, and tertiary) in a nonprotic solvent or with the alcohol itself as the solvent, in the presence of a metal salt, is described. This new method appears to be competitive with and/or alternative to the other methods previously reported.