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Synthesis 1994; 1994(8): 855-865
DOI: 10.1055/s-1994-25589
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Bryostatins: The Asymmetric Synthesis of the C1-C9 and C17-C27 Fragments

Jef De Brabander* , Maurits Vandewalle
  • *University of Gent, Department of Organic Chemistry, Laboratory for Organic Synthesis, Krijgslaan, 281 (S.4), B-9000 Gent, Belgium
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Publication Date:
17 September 2002 (online)

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The construction of the fragments C1-C9 3 and C17-C27, 4a of the bryostatins in a enantioselective and highly diastereoselective fashion is described. The usefulness of the "chiron" approach is illustrated with the synthesis of these fragments from, respectively, D-pantolactone (6) and D-isobutyl lactate (23) as chiral templates.