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Synlett 1995; 1995(2): 191-192
DOI: 10.1055/s-1995-4887
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Deprotonation of Ketones to Mn-Enolates by Phenylmanganese Chloride in the Presence of a Catalytic Amount of Amine

Gérard Cahiez* , Marwan Kanaan, Patrick Cléry
  • *Laboratoire de Chimie des Organoéléments (associé au CNRS, URA 473), Université P. et M. Curie, 4 Place Jussieu, F-75252 PARIS Cédex 05
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Publication Date:
31 December 2000 (online)

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Ketones are converted to Mn-enolates by treatment with phenylmanganese chloride in the presence of a catalytic amount of aromatic amine (7% to 20% of PhMeNH). Excellent yields have been obtained at 0°C in THF or preferably in a THF/sulfolane mixture. The kinetic enolates of Z configuration are mainly formed.

Manganese enolates - organomanganese reagents - monoalkylation of ketones - silyl enol esters - enol esters