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DOI: 10.1055/s-2002-33051
Copyright © 2002 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662
Absinthe: Return of the Green Fairy
Publication History
Publication Date:
12 August 2002 (online)
ABSTRACT
Among the most popular and intriguing intoxicants of the Victorian Age, absinthe had all but disappeared after it was banned in nearly all developed countries in the early 1900s. A number of great artists and writers from the late 1800s used absinthe as a social drink, including Vincent van Gogh and Toulouse-Lautrec. A recent resurgence of absinthe use has occurred in Europe and is rapidly spreading to the United States. Despite its increasing popularity limited information exists on the mechanism of action and neurotoxicity of absinthe. This paper reviews some of the historical aspects of absinthe and aims to shed light on the mechanism of action and neurotoxicology of this the Green Fairy.
KEYWORDS
Absinthe - thujone - van Gogh - neurotoxicology - history of medicine
REFERENCES
- 1 Arnold W N. Absinthe. Sci Am . 1989; 260 112-117
- 2 Anonymous. Lancet . 1906; 1531
- 3 Vogt D, Montagne M. Absinthe: behind the emerald mask. Int J Addict . 1982; 17 1015-1029
- 4 Shaw W. Little green men. Details. August, 1999: 60-62
- 5 Coughlin T. I drank with the devil. Maxim. October 1998 : 74-77
- 6 Hemphill R E. The illness of Vincent Van Gogh. Proc R Soc Med . 1961; 54 1083-1088
- 7 Arnold W. Vincent van Goh and thujone connection. JAMA . 1988; 260 3042-3044
- 8 Albert-Puleo M. Van Gogh's vision: thujone intoxication. JAMA . 1981; 246 42
- 9 Del Castillo J, Anderson M. Marijuana, absinthe and the central nervous system. Nature . 1975; 253 365-366
- 10 Meschler J, Howlett A. Thujone exhibits low affinity for cannabinoid receptors but fails to evoke cannabimimetic responses. Pharmaco Biochem Behav . 1999; 62 473-480
- 11 Hold K, Sirisoma N, Ikeda T. Alpha-thujone (the active component of absinthe): gamma-aminobutyric acid type A receptor modulation and metabolic detoxification. Proc Natl Acad Sci USA . 2000; 97 3826-3831
- 12 Bonkovsky H, Cable E, Cable J. Porphyrogenic properties of the terpenes camphor, pinene, and thujone. Biochem Pharmac . 1992; 43 2359-2368
- 13 Strang J, Arnold W N, Peters T. Absinthe: what's your poison?. <~>Though absinthe is intriguing, it is alcohol in general we should worry about. BMJ . 1999; 319 1590-1592
- 14 Anonymous. Absinthe and alcohol. Lancet . 1869; 1 334
- 15 Weisbord S, Soule J, Kimmel P. Poison on line: acute renal failure caused by oil of wormwood purchased through the internet. N Engl J Med . 1997; 337 825-827