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Planta Med 2002; 68(12): 1128-1131
DOI: 10.1055/s-2002-36355
Letter
© Georg Thieme Verlag Stuttgart · New York

Diayangambin Exerts Immunosuppressive and Anti-Inflammatory Effects in vitro and in vivo

Elvira J. De León1 , Dionisio A. Olmedo1 , Pablo N. Solís1 , Mahabir P. Gupta1 , M. Carmen Terencio2
  • 1Centro de Investigaciones Farmacognósticas de la Flora Panameña (CIFLORPAN), Facultad de Farmacia, Universidad de Panamá, Panamá
  • 2Departamento de Farmacología, Facultad de Farmacia, Universidad de Valencia, España
Further Information

Publication History

Received: April 17, 2002

Accepted: July 31, 2002

Publication Date:
20 December 2002 (online)

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Abstract

In this study, the furofuran lignan (+)-diayangambin [tetrahydro-1,4-bis(3,4,5-trimethoxyphenyl)-(1R)-1α,3aβ,4α,6aβ-1H,3H-furo [3,4-c]furan] was evaluated in vitro and in vivo for its immunomodulatory and anti-inflammatory efficacy. Human mononuclear cell proliferation was inhibited by diayangambin with an IC50 value of 1.5 (0.5 - 2.8) μM. In addition, the compound reduced for 40.8 % prostaglandin E2 generation in stimulated RAW 264.7 macrophage cell line at 10 μM. In vivo, a clear reduction of ear swelling was observed when diayangambin (40 mg/kg) was administered orally to 2,4-dinitrofluorobenzene-treated mice. The inhibition of swelling was associated with a reduction of leukocyte infiltration determined as myeloperoxidase activity. In the carrageenan mouse paw edema model, diayangambin significantly suppressed inflamed paw volume and prostaglandin E2 levels. Our findings indicate the potential interest of diayangambin in the treatment of immune and inflammatory responses.

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Dr. M. Carmen Terencio Silvestre

Departamento de Farmacología

Universidad de Valencia

Facultad de Farmacia

Avda. Vicent Andrés Estellés s/n

46100 Burjassot. Valencia

Spain

Email: Carmen.Terencio@uv.es

Fax: +34-96-3864943