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Synthesis 2003(8): 1201-1208
DOI: 10.1055/s-2003-39402
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Bicyclic Aminoalkyl N-Heterocycles by Ring-Chain-Transformation of Bridged­ 1,3-Dicarbonyl Heteroanalogues with Aminopyrazoles and Aminotriazole­

Magdalena Karanika,b, Michael Pätzela, Jürgen Liebscher*a
a Institut für Chemie, Humboldt-Universität Berlin, Brook-Taylor-Straße 2, 12489 Berlin, Germany
Fax: +49(30)20937552; e-Mail: liebscher@chemie.hu-berlin.de;
b Technical University of Szczecin, Institute of Fundamental Chemistry, Al. Piastow 42, 71-065 Szczecin, Poland
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Publication History

Received 26 January 2003
Publication Date:
26 May 2003 (online)

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Abstract

Reaction of cyclic iminium salts 3 as 1,3-dicarbonyl heteroanalogues with 2-aminoazoles 4 affords bicyclic ω-aminoalkyl N-heterocycles 7 and 11 in a straightforward one-step procedure by a ring-chain-transformation reaction. These products are analogues of interesting pharmaceutical compounds.

Key words

heterocycles - ring closure - ring opening - imines - amines

    References

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