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DOI: 10.1055/s-2004-829579
Development of the Ti-Catalyzed Intermolecular Hydroamination of Alkynes
Publikationsverlauf
Publikationsdatum:
15. Juli 2004 (online)

Abstract
This account describes the development of Ti-catalyzed intermolecular hydroamination reactions of alkynes, achieved in the author’s laboratories during the last five years. Starting from initial ideas and early results with Cp2TiMe2 as a catalyst precursor, mechanistic studies and applications of Cp2TiMe2-catalyzed hydroaminations of alkynes for the synthesis of biologically interesting classes of compounds are presented. Particular attention is paid to the identification of improved second generation catalysts such as Cp*2TiMe2 and Ind2TiMe2.
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1 Introduction
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2 Initial Ideas
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3 Cp2TiMe2: The First Generation Catalyst
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4 Cp*2TiMe2: The Improved Catalyst
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5 Other Titanium Catalysts
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6 Ind2TiMe2: The General Catalyst
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7 Hydroamination Reactions Employing Enantiomerically Pure Amines
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8 Applications for the Synthesis of Biologically Interesting Compounds
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9 Summary and Outlook
Key words
alkynes - aminations - amines - catalysis - titanium
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