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Synthesis 2005(4): 662-667
DOI: 10.1055/s-2004-831236
DOI: 10.1055/s-2004-831236
PSP
© Georg Thieme Verlag Stuttgart · New York
1-Isocyano-2-dimethylamino-alkenes: Versatile Reagents in Diversity-Oriented Organic Synthesis
Further Information
Received
1 June 2004
Publication Date:
21 October 2004 (online)
Publication History
Publication Date:
21 October 2004 (online)
Abstract
1-Isocyano-2-dimethylamino-alkenes are versatile and multifunctional reagents in organic synthesis. Two useful protocols are given for multicomponent reactions (MCRs) for the assembly of a 6-oxo-1,4,5,6-tetrahydropyrazine-2-carboxylic acid methyl ester derivative and a highly substituted thiazole. The procedures, in a modified set-up, are useful for array synthesis.
Key words
isocyanide - multicomponent reaction - heterocycle synthesis - thiazole
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