Deprotection of o-Nitrobenzensulfonyl (Nosyl) Derivatives of Amines ­Mediated by a Solid-Supported Thiol

Abstract

A new protocol based on a solid-supported thiol was ­developed for high yielding deprotection of o-nitrobenzensulfonyl amides derived from primary and secondary amines. The reaction can be carried out at room temperature for 24 hours or accelerated by microwave irradiation, going to completion in six minutes.

Key words

solid-supported reagents - amines - protecting groups - microwaves

References

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Commercially available form Aldrich or Argonaut.