Iron-Catalysed Reformatsky-Type Reactions

Abstract

A Reformatsky-type reaction has been developed using iron catalysis in acetonitrile or DMF. Reduction of iron(II) bromide by manganese metal in acetonitrile provides a low-valent iron catalyst, which is the active species; under these conditions, α-chloroesters or nitriles can both be converted into their corresponding derivatives. The method was applicable to both ketones and aldehydes, resulting in the formation of β-hydroxyesters under mild conditions.

Key words

iron - Reformatsky reaction - α-haloester - carbonyl compounds - C-C coupling

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1

New address: Dr. M. Durandetti, Laboratoire des Fonctions Azotées & Oxygénées Complexes de L’IRCOF, UMR 6014 CNRS, Université de Rouen, 76821 Mont Saint-Aignan Cedex, France.