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Synthesis 2008(6): 829-855
DOI: 10.1055/s-2008-1032202
DOI: 10.1055/s-2008-1032202
REVIEW
© Georg Thieme Verlag Stuttgart · New York
Applications of Zirconium(IV) Chloride in Organic Synthesis
Further Information
Received
8 November 2007
Publication Date:
28 February 2008 (online)
Publication History
Publication Date:
28 February 2008 (online)
Abstract
Zirconium(IV) chloride is used extensively in organic synthesis as an ideal Lewis acid since it is an efficient, stable, inexpensive, environmentally friendly and convenient catalyst for the preparation of useful synthetic intermediates and for use in key steps of natural products synthesis. This review is broadly divided into four sections based on zirconium(IV) chloride mediated reactions (1) carbon-carbon bond-formation reactions, (2) protection and deprotection chemistry, (3) reduction reactions, and (4) other applications. This review is an attempt to cover the important advances in the field of synthetic organic chemistry that have been carried out to date.
1 Introduction
2 Carbon-Carbon Bond-Formation Reactions
3 Protections and Deprotections
4 Reduction Reactions
5 Miscellaneous Reactions
6 Zirconium-Based Reagents and Complexes
7 Conclusions
Key words
zirconium(IV) chloride - Lewis acid - carbon-carbon bond formation - protection - deprotection - reduction
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References and Notes
Company overview of zrchem.com, manufacturers and suppliers of zirconium reagents. http://www.zrchem.com (accessed Feb 1, 2008).