Mouse models in haemostasis and thrombosis

Nigel Mackman

doi:10.1160/TH04-07-0414

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2004; 92(03): 440-443
DOI: 10.1160/TH04-07-0414

Theme Issue Editorial Focus

Schattauer GmbH

Mouse models in haemostasis and thrombosis

Nigel Mackman

¹The Scripps Research Institute, Department of Immunology, La Jolla, California, USA

References
1 Tsakiris DA, Scudder L, Hodivala-Dilke K. et al. Hemostasis in the mouse (Mus musculus): a review. Thromb Haemost 1999; 81: 177-88.
2 Hogan KA, Weiler H, Lord ST. Mouse models in coagulation. Thromb Haemost 2002; 87: 563-74.
3 Bi L, Lawler AM, Antonarakis SE. et al. Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A. Nat Genet 1995; 10: 119-21.
4 Lin HF, Maeda N, Smithies O. et al. A coagulation factor IX-deficient mouse model for human hemophilia B. Blood 1997; 90: 3962-6.
5 Suh TT, Holmback K, Jensen NJ. et al. Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice. Genes Dev 1995; 9: 2020-33.
6 Mackman N. Role of tissue factor in hemostasis, thrombosis, and vascular development. Arterioscler Thromb Vasc Biol 2004; 24: 1015-22.
7 Lauer P, Metzner HJ, Zettlmeissl G. et al. Targeted inactivation of the mouse locus encoding coagulation factor XIII-A: hemostatic abnormalities in mutant mice and characterization of the coagulation deficit. Thromb Haemost 2002; 88: 967-74.
8 Pawlinski R, Pedersen B, Erlich J. et al. Role of tissue factor in hemostasis, thrombosis, angiogenesis and inflammation: lesson from low tissue factor mice. Thromb Haemost 2004; 92: 444-50.
9 Pyo R, Sato Y, Mackman N. et al. Mice deficient in tissue factor demonstrate attenuated intimal hyperplasia in response to vascular injury and decreased smooth muscle cell migration. Thromb Haemost 2004; 92: 451-8.
10 Engelmann B, Luther T, Muller I. Intravascular tissue factor pathway – a model for rapid initiation of coagulation within the blood vessel. Thromb Haemost 2003; 89: 3-8.
11 Bogdanov VY, Balasubramanian V, Hathcock J. et al. Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein. Nat Med 2003; 9: 458-62.
12 Hrachovinova I, Cambien B, Hafezi-Moghadam A. et al. Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A. Nat Med 2003; 9: 1020-25.
13 Vandendries E, Furie B, Furie B. Role of Pselectin and PSGL-1 in coagulation and thrombosis. Thromb Haemost 2004; 92: 459-66.
14 Huang ZF, Higuchi D, Lasky N, Broze Jr GJ. Tissue factor pathway inhibitor gene disruption produces intrauterine lethality in mice. Blood 1997; 90: 944-51.
15 Jalbert LR, Rosen ED, Moons L. et al. Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice. J Clin Invest 1998; 102: 1481-8.
16 Ishiguro K, Kojima T, Kadomatsu K. et al. Complete antithrombin deficiency in mice results in embryonic lethality. J Clin Invest 2000; 106: 873-8.
17 Healy AM, Rayburn HB, Rosenberg RD. et al. Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system. Proc Natl Acad Sci U S A 1995; 92: 850-4.
18 Gu JM, Crawley JT, Ferrell G. et al. Disruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality. J Biol Chem 2002; 277: 43335-43.
19 Rosenberg RD, Aird WC. Vascular-bed – specific hemostasis and hypercoagulable states. N Engl J Med 1999; 340: 1555-64.
20 Weiler H. Mouse models of thrombosis: thrombomodulin. Thromb Haemost 2004; 92: 467-77.
21 Kato K, Martinez C, Russell S. et al. Genetic deletion of mouse platelet glycoprotein Ibβ produces a Bernard-Soulier phenotype with increased α-granule size. Blood. 2004 Epub ahead of print.
22 Hynes RO, Hodivala-Dilke KM. Insights and questions arising from studies of a mouse model of Glanzmann thrombasthenia. Thromb Haemost 1999; 82: 481-5.
23 Bergmeier W, Rabie T, Strehl A. et al. GPVI down-regulation in murine platelets through metalloproteinase-dependent shedding. Thromb Haemost 2004; 91: 951-8.
24 Nakanishi-Matsui M, Zheng YW, Sulciner DJ. et al. PAR3 is a cofactor for PAR4 activation by thrombin. Nature 2000; 404: 609-13.
25 Ware J. Dysfunctional platelet membrane receptors: from humans to mice. Thromb Haemost 2004; 92: 478-85.
26 Rosen ED, Raymond S, Zollman A. et al. Laser-induced noninvasive vascular injury models in mice generate platelet-and coagulation-dependent thrombi. Am J Pathol 2001; 158: 1613-22.
27 Li TT, Larrucea S, Souza S. et al. Genetic variation responsible for mouse strain differences in integrin alpha 2 expression is associated with altered platelet responses to collagen. Blood 2004; 103: 3396-402.
28 Day S, Reeve J, Myers D. et al. Murine thrombosis models. Thromb Haemost 2004; 92: 486-94.
29 Pan S, Kleppe LS, Witt WA. et al. The effect of vascular smooth muscle cell-targeted expression of tissue factor pathway inhibitor in a murine model of arterial thrombosis. Thromb Haemost 2004; 92: 495-502.
30 Pauer H-U, Renne T, Hemmerlein B. et al. Targeted deletion of murine coagulation factor XII gene-a model for contact phase activation in vivo. Thromb Haemost 2004; 92: 503-8.