The Thr715Pro single nucleotide polymorphism of P-selectin: does it really matter in cardiovascular or thrombotic disorders?

Bernd Jilma

doi:10.1160/TH04-09-0595

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2004; 92(05): 896-897
DOI: 10.1160/TH04-09-0595

Editorial Focus

Schattauer GmbH

The Thr715Pro single nucleotide polymorphism of P-selectin: does it really matter in cardiovascular or thrombotic disorders?

Bernd Jilma

¹Department of Clinical Pharmacology, Medical University Vienna, Austria

References
1 Carter AM, Anagnostopoulou K, Mansfield MW. et al. Soluble P-selectin levels, P-selectin polymorphisms and cardiovascular disease. J Thromb Haemost 2003; 01: 1718-23.
2 Miller MA, Kerry SM, Dong Y. et al. Association between the Thr715Pro P-selectin gene polymorphism and soluble P-selectin levels in a multiethnic population in South London. Thromb Haemost 2004; 92: 1060-5.
3 Blann AD, Nadar SK, Lip GY. The adhesion molecule P-selectin and cardiovascular disease. Eur Heart J 2003; 24: 2166-79.
4 Blann AD, Lip GY, Beevers DG. et al. Soluble P-selectin in atherosclerosis: a comparison with endothelial cell and platelet markers. Thromb Haemost 1997; 77: 1077-80.
5 Jilma B, Eichler HG, Vondrovec B. et al. Effects of desmopressin on circulating Pselectin. Br J Haematol 1996; 93: 432-6.
6 Fijnheer R, Frijns CJ, Korteweg J. et al. The origin of P-selectin as a circulating plasma protein. Thromb Haemost 1997; 77: 1081-5.
7 Stohlawetz P, Horvath M, Pernerstorfer T. et al. Effects of nitric oxide on platelet activation during plateletpheresis and in vivo tracking of biotinylated platelets in humans. Transfusion 1999; 39: 506-14.
8 Stohlawetz PJ, Dzirlo L, Hergovich N. et al. Effects of erythropoietin on platelet reactivity and thrombopoiesis in humans. Blood 2000; 95: 2983-9.
9 Jilma B, Eichler HG, Becherer A. et al. Kinetics of circulating selectin levels during bone marrow aplasia. Eur J Haematol 1998; 61: 36-41.
10 Herrmann SM, Ricard S, Nicaud V. et al. The P-selectin gene is highly polymorphic: reduced frequency of the Pro715 allele carriers in patients with myocardial infarction. Hum Mol Genet 1998; 07: 1277-84.
11 Kee F, Morrison C, Evans AE. et al. Polymorphisms of the P-selectin gene and risk of myocardial infarction in men and women in the ECTIM extension study. Etude cas-temoin de l’infarctus myocarde. Heart 2000; 84: 548-52.
12 Barbaux SC, Blankenberg S, Rupprecht HJ. et al. Association between P-selectin gene polymorphisms and soluble P-selectin levels and their relation to coronary artery disease. Arterioscler Thromb Vasc Biol 2001; 21: 1668-73.
13 Vandendries ER, Furie BC, Furie B. Role of P-selectin and PSGL-1 in coagulation and thrombosis. Thromb Haemost 2004; 92: 459-66.
14 Andre P. P-selectin in haemostasis. Br J Haematol 2004; 126: 298-306.
15 Hrachovinova I, Cambien B, Hafezi-Moghadam A. et al. Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A. Nat Med 2003; 09: 1020-25.