Download PDF
Vet Comp Orthop Traumatol 2008; 21(01): 64-68
DOI: 10.3415/VCOT-07-04-0040
Clinical Communication
Schattauer GmbH

Treatment with rhBMP-2 of extreme radial bone atrophy secondary to fracture management in an Italian Greyhound

F. Bernard
1   Surgery Unit, University College Dublin, Belfield, Dublin, Republic of Ireland
,
R. Furneaux
1   Surgery Unit, University College Dublin, Belfield, Dublin, Republic of Ireland
,
C. Adrega Da Silva
2   Clinique Veterinain, Neuilly-sur-Seine, France
,
J.-F. Bardet
2   Clinique Veterinain, Neuilly-sur-Seine, France
› Author Affiliations
Further Information

Publication History

Received 24 April 2007

Accepted 10 May 2007

Publication Date:
17 December 2017 (online)

Also available at
    Permissions and Reprints

Summary

rhBMP-2 solution on a collagen sponge was placed along the diaphysis of an atrophicradius, which had a history of recurring fractures. Two months after rhBMP-2 treatment, new mineralized bone was present, which significantly increased the diameter of the radius and allowed the removal of the external skeletal fixator (ESF). Due to carpo-metacarpal joint compromise, a pancarpal arthrodesis was performed seven months later. At follow-up evaluation two years later the dog was only very mildly lame.

Keywords

Bone - osteoporosis - atrophy - rhBMP - dog
 

  • References

  • 1 Welch JA, Boudrieau RJ, DeJardin LM. et al. The intraosseous blood supply of the canine radius: implications for healing of distal fractures in small dogs. Vet Surg 1997; 26: 57-61.
    CrossrefPubMedSearch in Google Scholar
  • 2 Aitola M, Sumner-Smith G. Nonunion fractures in dogs. JVet Orthoped 1984; 3: 21-24.
    PubMedSearch in Google Scholar
  • 3 Lappin MR, Aron DN, Herron HL. Fracture of the radius and ulna in the dog. J Am Anim Hosp Assoc 1982; 19: 643-650.
    PubMedSearch in Google Scholar
  • 4 Larsen LJ, Roush JK, McLaughlin RM. Bone plate fixation of distal radius and ulna fractures in small- and miniature-breed dogs. J Am Anim Hosp Assoc 1999; 35: 243-50.
    CrossrefPubMedSearch in Google Scholar
  • 5 Laverty PH, Johnson AL, Toombs JP. Simple and multiple fractures of the radius treated with an external fixator. Vet Comp Orthop Traumatol 2002; 15: 97-103.
    Thieme ConnectPubMedSearch in Google Scholar
  • 6 Saikku-Backstrom A, Raiha JE, Valimaa T. et al. Repair of radial fractures in toy breed dogs with self-reinforced biodegradable bone plates, metal screws, and light-weight external coaptation. Vet Surg 2005; 34: 11-17.
    CrossrefPubMedSearch in Google Scholar
  • 7 Sumner-Smith G. Delayedunions and nonunions: diagnosis, pathophysiology, and treatment. Vet Clin North Am Small Anim Pract 1991; 21: 745-760.
    CrossrefPubMedSearch in Google Scholar
  • 8 Field JR. Bone plate fixation: its relationship with implant induced osteoporosis. Vet Comp Orthop Traumatol 1997; 10: 88-94.
    Thieme ConnectPubMedSearch in Google Scholar
  • 9 Hunt JM, Aitken ML, Denny HR. et al. The complications of diaphyseal fractures in dogs: areview of 100 cases. J Small Anim Pract 1980; 21: 103-119.
    CrossrefPubMedSearch in Google Scholar
  • 10 Schmoekel HG, Weber FE, Hurter K. et al. Enhancement of bone healing using non-glycosyl- ated rhBMP-2 released from a fibrin matrix in dogs and cats. J Small Anim Pract 2005; 46: 17-21.
    CrossrefPubMedSearch in Google Scholar
  • 11 Pluhar GE, Manley PA, Heiner JP. et al. The effect of recombinant human bone morphogenetic pro- tein-2 on femoral reconstruction with an intercalary allograft in a dog model. J Orthop Res 2001; 19: 308-317.
    CrossrefPubMedSearch in Google Scholar
  • 12 Itoh T, Mochizuki M, Nishimura R. et al. Repair of ulnar segmental defect by recombinant human bone morphogenetic protein-2 in dogs. JVet Med Sci 1998; 60: 451-458.
    PubMedSearch in Google Scholar
  • 13 Sandhu HS, Kanim LE, Toth JM. et al. Experimental spinal fusion with recombinant human bone morphogenetic protein-2 without decortication of osseous elements. Spine 1997; 22: 1171-80.
    CrossrefPubMedSearch in Google Scholar
  • 14 Muschler GF, Hyodo A, Manning T. et al. Evaluation of human bone morphogenetic protein 2ina canine spinal fusion model. Clin Orthop RelatRes 1994; 308: 229-240.
    PubMedSearch in Google Scholar
  • 15 Toriumi DM, O'Grady K, Horlbeck DM. et al. Mandibular reconstruction using bone morpho- genetic protein 2: long-term follow-up in a canine model. Laryngoscope 1999; 109: 1481-1489.
    CrossrefPubMedSearch in Google Scholar
  • 16 Schmokel HG, Weber FE, Seiler G. et al. Treatment of nonunions with nonglycosylated recom- binant human bone morphogenetic protein-2 delivered from a fibrin matrix. Vet Surg 2004; 33: 112-118.
    CrossrefPubMedSearch in Google Scholar
  • 17 Kerwin SC, Lewis DD, Elkins AD. Bone grafting and banking. Compend Contin Educ Pract Vet 1991; 13: 1558-1566.
    PubMedSearch in Google Scholar
  • 18 Kirker-Head CA. Recombinant bone morphogenetic proteins: novel substances for enhancing bone healing. Vet Surg 1995; 245: 408-419.
    PubMedSearch in Google Scholar
  • 19 Waters DJ, Breur GJ, Toombs JP. Treatment of common forelimb fractures in miniature and toy- breed dogs. J Am Anim Hosp Assoc 1993; 29: 442-448.
    PubMedSearch in Google Scholar
  • 20 Lovell TP, Dawson EG, Nilsson OS. et al. Augmentation of spinal fusion with bone morphogenetic protein in dogs. Clin Orthop Relat Res 1989; 243: 266-274.
    PubMedSearch in Google Scholar
  • 21 David SM, Gruber HE, Meyer Jr. RA. et al. Lumbar spinal fusion using recombinant human bone morphogenetic protein in the canine. A comparison of three dosages and twocarriers. Spine 1999; 24: 1973-1979.
    PubMedSearch in Google Scholar
  • 22 Yudell Yudell, Block MS. Bone gap healing in the dog using recombinant human bone morphogenetic protein-2. J Oral Maxillofac Surg 2000; 58: 761-766.
    CrossrefPubMedSearch in Google Scholar
  • 23 Kokubo S, Mochizuki M, Fukushima S. et al. Long-term stability of bone tissues induced by an osteoinductive biomaterial, recombinant human bone morphogenetic protein-2 and a biodegradable carrier. Biomaterials 2004; 25: 1795-1803.
    CrossrefPubMedSearch in Google Scholar
  • 24 Faria ML, Lu Y, Heaney K. et al. Recombinant human bone morphogenetic protein-2 in absorb- able collagen sponge enhances bone healing of tibial osteotomies in dogs. Vet Surg 2007; 36: 122-131.
    CrossrefPubMedSearch in Google Scholar
  • 25 Boyne PJ, Marx RE, Nevins M. et al. A feasibility study evaluating rhBMP-2/absorbable collagen sponge for maxillary sinus floor augmentation. Int J Periodontics Restorative Dent 1997; 17: 11-25.
    PubMedSearch in Google Scholar
  • 26 Milovancev M, Muir P, Manley PA. et al. Clinical application of recombinant human bone morphogenetic protein-2 in 4 dogs. Vet Surg 2007; 36: 132-140.
    CrossrefPubMedSearch in Google Scholar