34.10.5 β-Fluoroamines (Update 2017)

Abstract

This chapter is an update to the earlier Science of Synthesis contribution (Section 34.10) describing methods for the synthesis of β-fluoroamines. This topic has continued to attract signficant attention from the synthetic community, largely due to the medicinal importance of this class of compounds. A wide variety of new methods have been developed, and this review focuses on examples that were published between 2005 and 2015.

Key words

aminofluorination - carbon—fluorine bonds - electrophilic fluorination - nucleophilic fluorination - radical fluorination - stereoselective reactions

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