Natural history of early gastric cancer: series of 21 cases

Hiroyoshi Iwagami; Ryu Ishihara; Kentaro Nakagawa; Masayasu Ohmori; Kenshi Matsuno; Shuntaro Inoue; Masamichi Arao; Taro Iwatsubo; Hiroko Nakahira; Noriko Matsuura; Satoki Shichijo; Akira Maekawa; Kanesaka Takashi; Sachiko Yamamoto; Yoji Takeuchi; Koji Higashino; Noriya Uedo; Isao Miyashiro

doi:10.1055/a-0746-3329

Endoscopy International Open, Table of Contents

CC BY-NC-ND 4.0 · Endosc Int Open 2019; 07(01): E43-E48
DOI: 10.1055/a-0746-3329

Case report

Natural history of early gastric cancer: series of 21 cases

Hiroyoshi Iwagami

¹Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan

,

Ryu Ishihara

¹Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan

,

Kentaro Nakagawa

¹Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan

,

Masayasu Ohmori

¹Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan

,

Kenshi Matsuno

¹Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan

,

Shuntaro Inoue

¹Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan

,

Masamichi Arao

¹Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan

,

Taro Iwatsubo

¹Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan

,

Hiroko Nakahira

¹Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan

,

Noriko Matsuura

¹Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan

,

Satoki Shichijo

¹Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan

,

Akira Maekawa

¹Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan

,

Kanesaka Takashi

¹Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan

,

Sachiko Yamamoto

¹Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan

,

Yoji Takeuchi

¹Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan

,

Koji Higashino

¹Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan

,

Noriya Uedo

¹Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan

,

Isao Miyashiro

²Division of Cancer Control Center, Osaka International Cancer Institute, Osaka, Japan

› Author Affiliations

Abstract

Background and study aims While knowledge of the natural history of early gastric cancer (EGC) may be useful in relevant clinical situations, few relevant reports are available. Therefore, we investigated the progression of EGC. We gathered data regarding 114 cases of EGC from 2005 to 2015 from a hospital cancer registry and analyzed 21 lesions that fulfilled five inclusion criteria. Deep progression was defined as submucosal invasion by a mucosal tumor and proper muscle invasion by a submucosal tumor. Lateral progression was defined as ≥ 20 % increase in size. During median follow-up of 23 months, one of 18 mucosal tumors showed deep progression and six showed lateral progression. Of three submucosal tumors, two showed deep progression and three showed lateral progression. Our study suggests that a certain proportion of mucosal cancers can lie dormant for several years. Further large-scale studies in a multicenter setting should overcome the limitations of this study.

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References

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