Reduced Fat Oxidation During Exercise in Post-Menopausal
                    Overweight-Obese Women with Higher Lipid Accumulation Product
                    Index

Elana Stein; Igor Martins Silva; Gilson P. Dorneles; Fabio Santos Lira; Pedro Romão; Alessandra Peres

doi:10.1055/a-0801-8730

Experimental and Clinical Endocrinology & Diabetes, Table of Contents

Exp Clin Endocrinol Diabetes 2020; 128(08): 556-562
DOI: 10.1055/a-0801-8730

Article

Reduced Fat Oxidation During Exercise in Post-Menopausal Overweight-Obese Women with Higher Lipid Accumulation Product Index

Authors

Elana Stein

¹Graduate Program in Nutrition Sciences, Laboratory of Cellular and Molecular Immunology, Federal University of Health Sciences of Porto Alegre Porto Alegre, RS, Brazil
Igor Martins Silva

²Graduate Program in Health Sciences, Laboratory of Cellular and Molecular Immunology, Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil
Gilson P. Dorneles

²Graduate Program in Health Sciences, Laboratory of Cellular and Molecular Immunology, Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil
Fabio Santos Lira

⁵Exercise and Immunometabolism Research Group, Post-Graduation Program in Movement Sciences, Department of Physical Education, State University of São Paulo – UNESP. School of Technology and Sciences, Presidente Prudente, Sao Paulo, Brazil
Pedro Romão

²Graduate Program in Health Sciences, Laboratory of Cellular and Molecular Immunology, Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil
Alessandra Peres

¹Graduate Program in Nutrition Sciences, Laboratory of Cellular and Molecular Immunology, Federal University of Health Sciences of Porto Alegre Porto Alegre, RS, Brazil

³Graduate Program in Rehabilitation Sciences, Laboratory of Cellular and Molecular Immunology, Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil

⁴Research Center, Graduate Program in Bioscience and Rehabilitation, Methodist University Center IPA, Porto Alegre, RS, Brazil

Abstract

Background and Aims The main aim of this study was to analyze how the lipid accumulation affects the whole-body fat oxidation over a range of intensities during a submaximal incremental exercise test in post-menopausal overweight-obese women.

Patients and Methods The maximal fat oxidation (MFO), the intensity where the MFO occurs (FatMax), fat oxidation were measured over a range of intensities during a submaximal incremental exercise test through indirect calorimetry in 60 postmenopausal overweight-obese women (aged>49 years; body mass index 28.0 to 39.0 kg/m²). The metabolic profile of participants was evaluated and the LAP index was calculated (waist-58×triglycerides [mmol/L]). A cutoff point of 34.5 was adopted and participant were designed as low LAP index (n=30) or high LAP index (n=30).

Results During submaximal exercise postmenopausal overweight-obese women with low LAP index showed a higher fat oxidation at 50% (0.53±0.05 vs. 0.45±0.12 g/min; p=0.01), 60% (0.40±0.06 vs. 0.31±0.16 g/min; p=0.02) and 70% (0.34±0.08 vs. 0.25±0.15 g/min; p=0.03) of VO_2Peak than those with high LAP index. No significant difference was observed in carbohydrate oxidation between groups (p>0.05) during exercise. Moreover, a significant difference in absolute MFO (p=0.018), MFO relative to free fat mass (p=0.043) and FatMax (p=0.002) was identified.

Conclusion Postmenopausal overweight-obese women who showed unhealthy metabolic phenotype evaluated through LAP index presented low fat oxidation during a submaximal incremental exercise.

Key words

fatmax - lipid oxidation - exercise - metabolism - obesity

Full Text

References

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