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CC BY-NC-ND 4.0 · Klin Monbl Augenheilkd 2019; 236(04): 492-510
DOI: 10.1055/a-0829-6763
Übersicht
Georg Thieme Verlag KG Stuttgart · New York

Vogt-Koyanagi-Harada Disease and Birdshot Retinochoroidopathy, Similarities and Differences: A Glimpse into the Clinicopathology of Stromal Choroiditis, a Perspective and a Review

Ähnlichkeiten und Unterschiede zwischen 2 stromalen Choroiditiden: Morbus Vogt-Koyanagi-Harada versus Birdshot-Retinochoroiditis
Sina Elahi
1   Ophthalmology, Clinique de Montchoisi, Chemin des Allinges, Lausanne, Switzerland
2   Retinal and Inflammatory Eye Diseases, Centre for Ophthalmic Specialized Care (COS), Rue Charles Monnard 6, Lausanne, Switzerland
,
Carl P. Herbort jr.
2   Retinal and Inflammatory Eye Diseases, Centre for Ophthalmic Specialized Care (COS), Rue Charles Monnard 6, Lausanne, Switzerland
› Author Affiliations
Further Information

Publication History

received 21 September 2018

accepted 05 December 2018

Publication Date:
19 March 2019 (online)

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Abstract

The purpose of this work was to give a comprehensive and updated review on two primary stromal choroiditis entities, Vogt-Koyanagi-Harada disease (VKH) and birdshot retinochoroiditis (BRC). Their appraisal has become much more precise thanks to new investigational methods, such as indocyanine green angiography (ICGA) and enhanced depth imaging optical coherence tomography (EDI-OCT), which give substantially improved imaging access to the choroid. In this review, we focus on the crucial changes brought by this progress in the understanding, diagnosis, and management of these disorders. Application of these methods makes it possible to reach an early diagnosis, therefore allowing early treatment, which has led to a profound improvement in outcomes when compared to previous management.

Zusammenfassung

Zweck dieser Arbeit war es, einen umfassenden und aktualisierten Überblick über 2 stromale Aderhautentzündungen (Choroiditis), Morbus Vogt-Koyanagi-Harada (VKH) und Birdshot-Retinochoroiditis (BRC), zu geben. Die Wahrnehmung von diesen 2 Aderhautentzündungen ist in der letzten Zeit viel präziser geworden dank neuer Investigationsmethoden wie Indocyaningrünangiografie (ICGA) und „Enhanced Depth Imaging Optical Coherence Tomography“ (EDI-OCT). Diese Methoden erlauben einen wesentlich besseren bildgebenden Zugang zu den Aderhautstrukturen. In diesem aktualisierten Überblick konzentrieren wir uns speziell auf die entscheidenden Änderungen, die diese Fortschritte zustande gebracht haben, was Verständnis, Diagnose und Behandlung dieser Erkrankungen anbelangt. Anwendung dieser Methoden macht es möglich, eine frühe Diagnose zu stellen, was wiederum eine frühe und aggressive Therapie ermöglicht. Solch eine Haltung hat zu einer signifikanten Verbesserung des Verlaufs gegenüber der gegenwärtig immer noch praktizierten Haltung erbracht. Ähnlichkeiten und Differenzen werden analysiert.

Key words

birdshot retinochoroiditis - Vogt-Koyanagi-Harada disease - stromal choroiditis - indocyanine green angiography - immunosuppressive therapy

Schlüsselwörter

Birdshot-Retinochoroiditis - Morbus Vogt-Koyanagi-Harada - stromale Aderhautentzündung - Indocyaningrünangiografie - immunosuppressive Therapie
 

  • References

  • 1 Forster DJ, Cano MR, Green RL. et al. Echographic features of the Vogt-Koyanagi-Harada syndrome. Arch Ophthalmol 1990; 108: 1421-1426
    CrossrefPubMedGoogle Scholar
  • 2 Ben Ezra D, Forrester JV. Fundal white dots: the spectrum of a similar pathological process. Br J Ophthalmol 1995; 79: 856-860
    CrossrefPubMedGoogle Scholar
  • 3 Herbort C. Choroiditis: general considerations and classification. In: Pleyer U, Mondino B. eds. Essentials in Ophthalmology: Uveitis and immunological Disorders. Berlin, Heidelberg, New York: Springer; 2004: 202-208
    Google Scholar
  • 4 Bouchenaki N, Herbort CO. Stromal choroiditis. In: Pleyer U, Mondino B. eds. Essentials in Ophthalmology: Uveitis and Immunological Disorders. Berlin Heidelberg, New York: Springer; 2004: 234-253
    Google Scholar
  • 5 Herbort CP, LeHoang P, Guex-Crosier Y. Schematic interpretation of indocyanine green angiography in posterior uveitis using a standard angiographic protocol. Ophthalmology 1998; 105: 432-440
    CrossrefPubMedGoogle Scholar
  • 6 Bouchenaki N, Cimino L, Auer C. et al. Assessment and classification of choroidal vasculitis in posterior uveitis using indocyanine green angiography. Klin Monatsbl Augenheilkd 2002; 219: 243-249
    Article in Thieme ConnectPubMedGoogle Scholar
  • 7 Herbort CP, Papadia M, Mantovani A. Classification of choroiditis based on inflammatory lesion process rather than fundus appearance: enhanced comprehension through the ICGA concepts of the iceberg and jellyfish effects. Klin Monatsbl Augenheilkd 2012; 229: 306-313
    Article in Thieme ConnectPubMedGoogle Scholar
  • 8 Cimino L, Auer C, Herbort CP. Sensitivity of indocyanine green angiography for the follow-up of active inflammatory choriocapillaropathies. Ocul Immunol Inflamm 2000; 8: 275-283
    CrossrefPubMedGoogle Scholar
  • 9 Gillmann K, El Ameen A, Massy R. et al. Assessment of measurement methods of posterior inflammation in stromal choroiditis: the value of quantitative outcome measures versus the presently qualitatively based paradigm. Int Ophthalmol 2018; DOI: 10.1007/s10792-018-0979-y.
    CrossrefPubMedGoogle Scholar
  • 10 Fabro F, Herbort CP. Need for Quantitative Measurement Methods for Posterior Uveitis: Comparison of Dual FA/ICGA Angiography, EDI-OCT Choroidal Thickness and SUN Vitreous Haze Evaluation in Stromal Choroiditis. Klin Monatsbl Augenheilkd 2018; 235: 424-435
    Article in Thieme ConnectPubMedGoogle Scholar
  • 11 Herbort CP. Posterior uveitis: new insights provided by indocyanine green angiography. Eye (Lond) 1998; 12: 757-759
    CrossrefPubMedGoogle Scholar
  • 12 Herbort CP, Mantovani A, Papadia M. Use of indocyanine green angiography in uveitis. Int Ophthalmol Clin 2012; 52: 13-31
    CrossrefPubMedGoogle Scholar
  • 13 Herbort CP, Neri P, El Asrar AA. et al. Is ICGA still relevant in inflammatory eye disorders? Why this question has to be dealt with separately from other eye conditions. Retina 2012; 32: 1701-1703
    CrossrefPubMedGoogle Scholar
  • 14 Yannuzzi LA. Indocyanine green angiography: a perspective on use in the clinical setting. Am J Ophthalmol 2011; 151: 745-751.e1
    CrossrefPubMedGoogle Scholar
  • 15 Tugal-Tutkun I, Herbort CP, Khairallah M. Angiography Scoring for Uveitis Working Group. Scoring of dual fluorescein and ICG inflammatory angiographic signs for the grading of posterior segment inflammation (dual fluorescein and ICG angiographic scoring system for uveitis). Int Ophthalmol 2010; 30: 539-552
    CrossrefPubMedGoogle Scholar
  • 16 Tugal-Tutkun I, Herbort CP, Khairallah M. et al. Interobserver agreement in scoring of dual fluorescein and ICG inflammatory angiographic signs for the grading of posterior segment inflammation. Ocul Immunol Inflamm 2010; 18: 385-389
    CrossrefPubMedGoogle Scholar
  • 17 Lavezzo MM, Sakata VM, Morita C. et al. Vogt-Koyanagi-Harada disease: review of a rare autoimmune disease targeting antigens of melanocytes. Orphanet J Rare Dis 2016; 11: 29
    CrossrefPubMedGoogle Scholar
  • 18 Vogt A. Frühzeitiges ergrauen der Zilien und Bermerkungen über den sogenannten plötzlichen Eintritt dieser Veränderung. Klin Monatsbl Augenheilkd 1906; 44: 228-242
    PubMedGoogle Scholar
  • 19 Herbort CP, Mochizuki M. Vogt-Koyanagi-Harada disease: inquiry into the genesis of a disease name in the historical context of Switzerland and Japan. Int Ophthalmol 2007; 27: 67-79
    CrossrefPubMedGoogle Scholar
  • 20 Koyanagi Y. Poliosis and alopecia associated with idiopathic uveitis. Acta Soc Ophthalmol Jpn 1914; 18: 1188-1192
    PubMedGoogle Scholar
  • 21 Harada E. Jikken Ganka Zasshi 1918; 2: 199
    PubMed
  • 22 Harada E. Beitrag zur klinischen Kenntnis von Michteitriger Choroiditis (choroiditis diffusa acta). Acta Soc Ophthalmol Jpn 1926; 30: 356-378
    PubMedGoogle Scholar
  • 23 Koyanagi Y. Dysakusis, Alopecia und Poliosis bei schwerer Uveitis nicht traumatischen Ursprungs. Klin Monatsbl Augenheilkd 1929; 82: 194-211
    PubMedGoogle Scholar
  • 24 Babel J. Syndrome de Vogt-Koyanagi (Uveite bilateral, poliosis, alopecie, vitiligo et dysacousie). Schweiz Med Wochenschr 1932; 44: 1136-1140
    PubMedGoogle Scholar
  • 25 Bruno MG, McPherson jr. SD. Haradaʼs disease. Am J Ophthalmol 1949; 32: 513-522
    CrossrefPubMedGoogle Scholar
  • 26 Gocho K, Kondo I, Yamaki K. Identification of autoreactive T cells in Vogt-Koyanagi-Harada disease. Invest Ophthalmol Vis Sci 2001; 42: 2004-2009
    PubMedGoogle Scholar
  • 27 Damico FM, Cunha-Neto E, Goldberg AC. et al. T-cell recognition and cytokine profile induced by melanocyte epitopes in patients with HLA-DRB1*0405-positive and -negative Vogt-Koyanagi-Harada uveitis. Invest Ophthalmol Vis Sci 2005; 46: 2465-2471
    CrossrefPubMedGoogle Scholar
  • 28 Sugita S, Takase H, Taguchi C. et al. Ocular infiltrating CD4+ T cells from patients with Vogt-Koyanagi-Harada disease recognize human melanocyte antigens. Invest Ophthalmol Vis Sci 2006; 47: 2547-2554
    CrossrefPubMedGoogle Scholar
  • 29 Yokoyama MM, Matsui Y, Yamashiroya HM. et al. Humoral and cellular immunity studies in patients with Vogt-Koyanagi-Harada syndrome and pars planitis. Invest Ophthalmol Vis Sci 1981; 20: 364-370
    PubMedGoogle Scholar
  • 30 Tran VT, Auer C, Guex-Crosier Y. et al. Epidemiological characteristics of uveitis in Switzerland. Int Ophthalmol 1994; 18: 293-298
    CrossrefPubMedGoogle Scholar
  • 31 Ohno S, Char DH, Kimura SJ. et al. Vogt-Koyanagi-Harada syndrome. Am J Ophthalmol 1977; 83: 735-740
    CrossrefPubMedGoogle Scholar
  • 32 Murakami S, Inaba Y, Mochizuki M. et al. A nationwide survey on the occurrence of Vogt-Koyanagi-Harada disease in Japan. Jpn J Ophthalmol 1994; 38: 208-213
    PubMedGoogle Scholar
  • 33 Mantovani A, Resta A, Herbort CP. et al. Work-up, diagnosis and management of acute Vogt-Koyanagi-Harada disease: a case of acute myopization with granulomatous uveitis. Int Ophthalmol 2007; 27: 105-115
    CrossrefPubMedGoogle Scholar
  • 34 Sugiura S. Vogt-Koyanagi-Harada disease. Jpn J Ophthalmol 1978; 22: 9-35
    PubMedGoogle Scholar
  • 35 Snyder DA, Tessler HH. Vogt-Koyanagi-Harada syndrome. Am J Ophthalmol 1980; 90: 69-75
    CrossrefPubMedGoogle Scholar
  • 36 Read RW, Holland GN, Rao NA. et al. Revised diagnostic criteria for Vogt-Koyanagi-Harada disease: report of an international committee on nomenclature. Am J Ophthalmol 2001; 131: 647-652
    CrossrefPubMedGoogle Scholar
  • 37 Herbort jr. CP, Abu El Asrar AM, Takeuchi M. et al. Catching the therapeutic window of opportunity in early initial-onset Vogt-Koyanagi-Harada uveitis can cure the disease. Int Ophthalmol 2018; DOI: 10.1007/s10792-018-0949-4.
    CrossrefPubMedGoogle Scholar
  • 38 Chee SP, Chan SN, Jap A. Comparison of Enhanced Depth Imaging and Swept Source Optical Coherence Tomography in Assessment of Choroidal Thickness in Vogt-Koyanagi-Harada Disease. Ocul Immunol Inflamm 2017; 25: 528-532
    CrossrefPubMedGoogle Scholar
  • 39 Khairallah AS. Headache as an initial manifestation of Vogt-Koyanagi-Harada disease. Saudi J Ophthalmol 2014; 28: 239-242
    CrossrefPubMedGoogle Scholar
  • 40 Kosma KK, Kararizou E, Markou I. et al. Headache as a first manifestation of Vogt-Koyanagi-Harada disease. Med Princ Pract 2008; 17: 253-254
    CrossrefPubMedGoogle Scholar
  • 41 Allegri P, Rissotto R, Herbort CP. et al. CNS diseases and uveitis. J Ophthalmic Vis Res 2011; 6: 284-308
    PubMedGoogle Scholar
  • 42 Yang P, Ren Y, Li B. et al. Clinical characteristics of Vogt-Koyanagi-Harada syndrome in Chinese patients. Ophthalmology 2007; 114: 606-614
    CrossrefPubMedGoogle Scholar
  • 43 Noguchi Y, Nishio A, Takase H. et al. Audiovestibular findings in patients with Vogt-Koyanagi-Harada disease. Acta Otolaryngol 2014; 134: 339-344
    CrossrefPubMedGoogle Scholar
  • 44 Fang W, Zhou H, Yang P. et al. Longitudinal quantification of aqueous flare and cells in Vogt-Koyanagi-Harada disease. Br J Ophthalmol 2008; 92: 182-185
    CrossrefPubMedGoogle Scholar
  • 45 Keino H, Goto H, Usui M. Sunset glow fundus in Vogt-Koyanagi-Harada disease with or without chronic ocular inflammation. Graefes Arch Clin Exp Ophthalmol 2002; 240: 878-882
    CrossrefPubMedGoogle Scholar
  • 46 Keino H, Goto H, Mori H. et al. Association between severity of inflammation in CNS and development of sunset glow fundus in Vogt-Koyanagi-Harada disease. Am J Ophthalmol 2006; 141: 1140-1142
    CrossrefPubMedGoogle Scholar
  • 47 Abu El-Asrar AM, Hemachandran S, Al-Mezaine HS. et al. The outcomes of mycophenolate mofetil therapy combined with systemic corticosteroids in acute uveitis associated with Vogt-Koyanagi-Harada disease. Acta Ophthalmol 2012; 90: e603-e608
    CrossrefPubMedGoogle Scholar
  • 48 Bacsal K, Wen DS, Chee SP. Concomitant choroidal inflammation during anterior segment recurrence in Vogt-Koyanagi-Harada disease. Am J Ophthalmol 2008; 145: 480-486
    CrossrefPubMedGoogle Scholar
  • 49 Wu L, Evans T, Saravia M. et al. Intravitreal bevacizumab for choroidal neovascularization secondary to Vogt-Koyanagi-Harada syndrome. Jpn J Ophthalmol 2009; 53: 57-60
    CrossrefPubMedGoogle Scholar
  • 50 Moorthy RS, Mermoud A, Baerveldt G. et al. Glaucoma associated with uveitis. Surv Ophthalmol 1997; 41: 361-394
    CrossrefPubMedGoogle Scholar
  • 51 Herbort CP. Fluorescein and indocyanine green angiography for uveitis. Middle East Afr J Ophthalmol 2009; 16: 168-187
    PubMedGoogle Scholar
  • 52 Bouchenaki N, Herbort CP. The contribution of indocyanine green angiography to the appraisal and management of Vogt-Koyanagi-Harada disease. Ophthalmology 2001; 108: 54-64
    CrossrefPubMedGoogle Scholar
  • 53 Bouchenaki N, Herbort CP. Indocyanine green angiography guided management of vogt-koyanagi-harada disease. J Ophthalmic Vis Res 2011; 6: 241-248
    PubMedGoogle Scholar
  • 54 Balci O, Gasc A, Jeannin B. et al. Enhanced depth imaging is less suited than indocyanine green angiography for close monitoring of primary stromal choroiditis: a pilot report. Int Ophthalmol 2017; 37: 737-748
    CrossrefPubMedGoogle Scholar
  • 55 Yuzawa M, Kawamura A, Matsui M. Indocyanine green video-angiographic findings in Haradaʼs disease. Jpn J Ophthalmol 1993; 37: 456-466
    PubMedGoogle Scholar
  • 56 Harada T, Kanbara Y, Takeuchi T. et al. Exploration of Vogt-Koyanagi-Harada syndrome by infrared choroidal angiography with indocyanine green. Eur J Ophthalmol 1997; 7: 163-170
    CrossrefPubMedGoogle Scholar
  • 57 Herbort CP, Mantovani A, Bouchenaki N. Indocyanine green angiography in Vogt-Koyanagi-Harada disease: angiographic signs and utility in patient follow-up. Int Ophthalmol 2007; 27: 173-182
    CrossrefPubMedGoogle Scholar
  • 58 Miyanaga M, Kawaguchi T, Miyata K. et al. Indocyanine green angiography findings in initial acute pretreatment Vogt-Koyanagi-Harada disease in Japanese patients. Jpn J Ophthalmol 2010; 54: 377-382
    CrossrefPubMedGoogle Scholar
  • 59 Abouammoh MA, Gupta V, Hemachandran S. et al. Indocyanine green angiographic findings in initial-onset acute Vogt-Koyanagi-Harada disease. Acta Ophthalmol 2016; 94: 573-578
    CrossrefPubMedGoogle Scholar
  • 60 Liu XY, Peng XY, Wang S. et al. Features of optical coherence tomography for the diagnosis of Vogt-Koyanagi-Harada disease. Retina 2016; 36: 2116-2123
    CrossrefPubMedGoogle Scholar
  • 61 Nakayama M, Keino H, Okada AA. et al. Enhanced depth imaging optical coherence tomography of the choroid in Vogt-Koyanagi-Harada disease. Retina 2012; 32: 2061-2069
    CrossrefPubMedGoogle Scholar
  • 62 Nakai K, Gomi F, Ikuno Y. et al. Choroidal observations in Vogt-Koyanagi-Harada disease using high-penetration optical coherence tomography. Graefes Arch Clin Exp Ophthalmol 2012; 250: 1089-1095
    CrossrefPubMedGoogle Scholar
  • 63 Kitaichi N, Matoba H, Ohno S. The positive role of lumbar puncture in the diagnosis of Vogt-Koyanagi-Harada disease: lymphocyte subsets in the aqueous humor and cerebrospinal fluid. Int Ophthalmol 2007; 27: 97-103
    CrossrefPubMedGoogle Scholar
  • 64 Herbort jr. CP, Abu El Asrar AM, Yamamoto JH. et al. Reappraisal of the management of Vogt-Koyanagi-Harada disease: sunset glow fundus is no more a fatality. Int Ophthalmol 2017; 37: 1383-1395
    CrossrefPubMedGoogle Scholar
  • 65 Kawaguchi T, Horie S, Bouchenaki N. et al. Suboptimal therapy controls clinically apparent disease but not subclinical progression of Vogt-Koyanagi-Harada disease. Int Ophthalmol 2010; 30: 41-50
    CrossrefPubMedGoogle Scholar
  • 66 Zmuda M, Tiev KP, Knoeri J. et al. Successful use of infliximab therapy in sight-threatening corticosteroid-resistant Vogt-Koyanagi-Harada disease. Ocul Immunol Inflamm 2013; 21: 310-316
    CrossrefPubMedGoogle Scholar
  • 67 Elahi SG, Gasc K, Jeannin A. et al. Sensitivity of ICGA compared to FA and EDI-OCT during tapering and fine-tuning of therapy in primary stromal choroiditis: a case series. J Curr Ophthalmol 2018; DOI: 10.1016/j.joco.2018.12.006.
    CrossrefPubMedGoogle Scholar
  • 68 Ryan SJ, Maumenee AE. Birdshot retinochoroidopathy. Am J Ophthalmol 1980; 89: 31-45
    CrossrefPubMedGoogle Scholar
  • 69 Gass JD. Vitiliginous chorioretinitis. Arch Ophthalmol 1981; 99: 1778-1787
    CrossrefPubMedGoogle Scholar
  • 70 Nussenblatt RB, Mittal KK, Ryan S. et al. Birdshot retinochoroidopathy associated with HLA-A29 antigen and immune responsiveness to retinal S-antigen. Am J Ophthalmol 1982; 94: 147-158
    CrossrefPubMedGoogle Scholar
  • 71 LeHoang P, Ozdemir N, Benhamou A. et al. HLA-A29.2 subtype associated with birdshot retinochoroidopathy. Am J Ophthalmol 1992; 113: 33-35
    CrossrefPubMedGoogle Scholar
  • 72 Papadia M, Herbort CP. Reappraisal of birdshot retinochoroiditis (BRC): a global approach. Graefes Arch Clin Exp Ophthalmol 2013; 251: 861-869
    CrossrefPubMedGoogle Scholar
  • 73 Herbort CP, Probst K, Cimino L. et al. Differential inflammatory involvement in retina and choroid in birdshot chorioretinopathy. Klin Monatsbl Augenheilkd 2004; 221: 351-356
    Article in Thieme ConnectPubMedGoogle Scholar
  • 74 Gaudio PA, Kaye DB, Crawford JB. Histopathology of birdshot retinochoroidopathy. Br J Ophthalmol 2002; 86: 1439-1441
    CrossrefPubMedGoogle Scholar
  • 75 Matsumoto Y, Haen SP, Spaide RF. The white dot syndromes. Compr Ophthalmol Update 2007; 8: 179-200 discussion 203–204
    PubMedGoogle Scholar
  • 76 Papadia M, Herbort jr. CP. New concepts in the appraisal and management of birdshot retinochoroiditis, a global perspective. Int Ophthalmol 2015; 35: 287-301
    CrossrefPubMedGoogle Scholar
  • 77 Guex-Crosier Y, Herbort CP. Prolonged retinal arterio-venous circulation time by fluorescein but not by indocyanine green angiography in birdshot chorioretinopathy. Ocul Immunol Inflamm 1997; 5: 203-206
    CrossrefPubMedGoogle Scholar
  • 78 Papadia M, Jeannin B, Herbort CP. OCT findings in birdshot chorioretinitis: a glimpse into retinal disease evolution. Ophthalmic Surg Lasers Imaging 2012; 43 (Suppl. 06) S25-S31
    CrossrefPubMedGoogle Scholar
  • 79 Baarsma GS, Priem HA, Kijlstra A. Association of birdshot retinochoroidopathy and HLA-A29 antigen. Curr Eye Res 1990; 9 (Suppl.) 63-68
    CrossrefPubMedGoogle Scholar
  • 80 Tran VT, Auer C, Guex-Crosier Y. et al. Epidemiology of uveitis in Switzerland. Ocul Immunol Inflamm 1994; 2: 169-176
    CrossrefPubMedGoogle Scholar
  • 81 Minos E, Barry RJ, Southworth S. et al. Birdshot chorioretinopathy: current knowledge and new concepts in pathophysiology, diagnosis, monitoring and treatment. Orphanet J Rare Dis 2016; 11: 61
    CrossrefPubMedGoogle Scholar
  • 82 Levinson RD, Brezin A, Rothova A. et al. Research criteria for the diagnosis of birdshot chorioretinopathy: results of an international consensus conference. Am J Ophthalmol 2006; 141: 185-187
    CrossrefPubMedGoogle Scholar
  • 83 Knecht PB, Papadia M, Herbort CP. Granulomatous keratic precipitates in birdshot retinochoroiditis. Int Ophthalmol 2013; 33: 133-137
    CrossrefPubMedGoogle Scholar
  • 84 Herbort jr. CP, Pavesio C, LeHoang P. et al. Why birdshot retinochoroiditis should rather be called ʼHLA-A29 uveitisʼ?. Br J Ophthalmol 2017; 101: 851-855
    CrossrefPubMedGoogle Scholar
  • 85 de Courten C, Herbort CP. Potential role of computerized visual field testing for the appraisal and follow-up of birdshot chorioretinopathy. Arch Ophthalmol 1998; 116: 1389-1391
    PubMedGoogle Scholar
  • 86 Cimino L. Importance of visual field testing in the functional evaluation and follow-up of birdshot chorioretinopathy. Ophthalmic Res 2002; 34: 141
    PubMedGoogle Scholar
  • 87 Arya B, Westcott M, Robson AG. et al. Pointwise linear regression analysis of serial Humphrey visual fields and a correlation with electroretinography in birdshot chorioretinopathy. Br J Ophthalmol 2015; 99: 973-978
    CrossrefPubMedGoogle Scholar
  • 88 Guex-Crosier Y, Pittet N, Herbort CP. Sensitivity of laser flare photometry to monitor inflammation in uveitis of the posterior segment. Ophthalmology 1995; 102: 613-621
    CrossrefPubMedGoogle Scholar
  • 89 Knecht PB, Papadia M, Herbort jr. CP. Early and sustained treatment modifies the phenotype of birdshot retinochoroiditis. Int Ophthalmol 2014; 34: 563-574
    CrossrefPubMedGoogle Scholar
  • 90 Balci O, Jeannin B, Herbort jr. CP. Contribution of dual fluorescein and indocyanine green angiography to the appraisal of posterior involvement in birdshot retinochoroiditis and Vogt-Koyanagi-Harada disease. Int Ophthalmol 2018; 38: 527-539
    CrossrefPubMedGoogle Scholar
  • 91 Priem HA, De Rouck A, De Laey JJ. et al. Electrophysiologic studies in birdshot chorioretinopathy. Am J Ophthalmol 1988; 106: 430-466
    CrossrefPubMedGoogle Scholar
  • 92 Holder GE, Robson AG, Pavesio C. et al. Electrophysiological characterisation and monitoring in the management of birdshot chorioretinopathy. Br J Ophthalmol 2005; 89: 709-718
    CrossrefPubMedGoogle Scholar
  • 93 Fardeau C, Herbort CP, Kullmann N. et al. Indocyanine green angiography in birdshot chorioretinopathy. Ophthalmology 1999; 106: 1928-1934
    CrossrefPubMedGoogle Scholar
  • 94 Tugal-Tutkun I, Herbort CP, Khairallah M. Scoring of dual fluorescein and ICG inflammatory angiographic signs for the grading of posterior segment inflammation (dual fluorescein and ICG angiographic scoring system for uveitis). Int Ophthalmol 2010; 30: 539-552
    CrossrefPubMedGoogle Scholar
  • 95 Skvortsova N, Gasc A, Jeannin B. et al. Evolution of choroidal thickness over time and effect of early and sustained therapy in birdshot retinochoroiditis. Eye (Lond) 2017; 31: 1205-1211
    CrossrefPubMedGoogle Scholar
  • 96 Phasukkijwatana N, Iafe N, Sarraf D. Optical Coherence Tomography Angiography of A29 Birdshot Chorioretinopathy Complicated by Retinal Neovascularization. Retin Cases Brief Rep 2017; 11 (Suppl. 01) S68-S72
    CrossrefPubMedGoogle Scholar
  • 97 Pohlmann D, Macedo S, Stubiger N. et al. Multimodal Imaging in Birdshot Retinochoroiditis. Ocul Immunol Inflamm 2017; 25: 621-632
    PubMedGoogle Scholar
  • 98 de Carlo TE, Bonini Filho MA, Adhi M. et al. Retinal and Choroidal Vasculature in Birdshot Chorioretinopathy Analyzed Using Spectral Domain Optical Coherence Tomography Angiography. Retina 2015; 35: 2392-2399
    CrossrefPubMedGoogle Scholar
  • 99 Rothova A, Berendschot TT, Probst K. et al. Birdshot chorioretinopathy: long-term manifestations and visual prognosis. Ophthalmology 2004; 111: 954-959
    CrossrefPubMedGoogle Scholar
  • 100 Levinson RD, Gonzales CR. Birdshot retinochoroidopathy: immunopathogenesis, evaluation, and treatment. Ophthalmol Clin North Am 2002; 15: 343-350 vii
    CrossrefPubMedGoogle Scholar
  • 101 Becker MD, Wertheim MS, Smith JR. et al. Long-term follow-up of patients with birdshot retinochoroidopathy treated with systemic immunosuppression. Ocul Immunol Inflamm 2005; 13: 289-293
    CrossrefPubMedGoogle Scholar
  • 102 Vitale AT, Rodriguez A, Foster CS. Low-dose cyclosporine therapy in the treatment of birdshot retinochoroidopathy. Ophthalmology 1994; 101: 822-831
    CrossrefPubMedGoogle Scholar
  • 103 Godel V, Baruch E, Lazar M. Late development of chorioretinal lesions in birdshot retinochoroidopathy. Ann Ophthalmol 1989; 21: 49-52
    PubMedGoogle Scholar
  • 104 Kaplan HJ, Aaberg TM. Birdshot retinochoroidopathy. Am J Ophthalmol 1980; 90: 773-782
    CrossrefPubMedGoogle Scholar
  • 105 Christmas NJ, Oh KT, Oh DM. et al. Long-term follow-up of patients with serpinginous choroiditis. Retina 2002; 22: 550-556
    CrossrefPubMedGoogle Scholar
  • 106 Le Hoang P, Girard B, Deray G. et al. Cyclosporine in the treatment of birdshot retinochoroidopathy. Transplant Proc 1988; 20 (3 Suppl. 4): 128-130
    PubMedGoogle Scholar
  • 107 Leder HA, Galor A, Thorne JE. et al. Disappearance of classic birdshot spots after immunosuppression with tacrolimus and mycophenolate mofetil. Br J Ophthalmol 2008; 92: 291
    PubMedGoogle Scholar
  • 108 Cao JH, Silpa-Archa S, Freitas-Neto CA. et al. Birdshot chorioretinitis lesions on indocyanine green angiography as an indicator of disease activity. Retina 2016; 36: 1751-1757
    CrossrefPubMedGoogle Scholar