Update Breast Cancer 2019 Part 1 – Implementation of Study Results of Novel Study Designs in Clinical Practice in Patients with Early Breast Cancer

Andreas D. Hartkopf; Volkmar Müller; Achim Wöckel; Michael P. Lux; Wolfgang Janni; Naiba Nabieva; Florin-Andrei Taran; Johannes Ettl; Diana Lüftner; Erik Belleville; Florian Schütz; Peter A. Fasching; Tanja N. Fehm; Hans-Christian Kolberg; Friedrich Overkamp; Andreas Schneeweiss; Hans Tesch

doi:10.1055/a-0842-6614

Geburtshilfe und Frauenheilkunde, Table of Contents

CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2019; 79(03): 256-267
DOI: 10.1055/a-0842-6614

GebFra Science

Review/Übersicht

Georg Thieme Verlag KG Stuttgart · New York

Update Mammakarzinom 2019 Teil 1 – Implementierung der Ergebnisse neuer Studienkonzepte beim frühen Mammakarzinom in die klinische Praxis

Article in several languages: English | deutsch

Andreas D. Hartkopf

¹Department of Obstetrics and Gynecology, University of Tübingen, Tübingen, Germany

,

Volkmar Müller

²Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany

,

Achim Wöckel

³Department of Gynecology and Obstetrics, University Hospital Würzburg, Würzburg, Germany

,

Michael P. Lux

⁴Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

,

Wolfgang Janni

⁵Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany

,

Naiba Nabieva

⁴Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

,

Florin-Andrei Taran

¹Department of Obstetrics and Gynecology, University of Tübingen, Tübingen, Germany

,

Johannes Ettl

⁶Department of Obstetrics and Gynecology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany

,

Diana Lüftner

⁷Charité University Hospital, Campus Benjamin Franklin, Department of Hematology, Oncology and Tumour Immunology, Berlin, Germany

,

Erik Belleville

⁸ClinSol GmbH & Co. KG, Würzburg, Germany

,

Florian Schütz

⁹Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany

,

Peter A. Fasching

⁴Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

,

Tanja N. Fehm

¹⁰Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Düsseldorf, Germany

,

Hans-Christian Kolberg

¹¹Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop, Germany

,

Friedrich Overkamp

¹²OncoConsult Hamburg GmbH, Hamburg, Germany

,

Andreas Schneeweiss

¹³National Center for Tumor Diseases, Division Gynecologic Oncology, University Hospital Heidelberg, Heidelberg, Germany

,

Hans Tesch

¹⁴Oncology Practice at Bethanien Hospital Frankfurt, Frankfurt, Germany

› Author Affiliations

Abstract

Zusammenfassung

In der Prävention und Behandlung des frühen Mammakarzinoms sind über die Jahre immer wieder kleine, aber bedeutsame Fortschritte gemacht worden. In der Prävention gewinnen die sogenannten Panel-Gen-Analysen immer mehr an Bedeutung, da das durch die getesteten Gene bedingte Risiko immer besser verstanden wird und somit Konzepte für die Integration in die Krankenversorgung erarbeitet werden können. In der adjuvanten Situation konnte die erste Studie in der sogenannten postneoadjuvanten Situation bei fehlender pathologischer Komplettremission nach Trastuzumab oder Pertuzumab + Trastuzumab eine deutliche Verbesserung der Prognose zeigen. Weitere Studien mit diesem postneoadjuvanten Therapiekonzept werden zurzeit noch durchgeführt. Die CDK4/6-Inhibitoren, die in der metastasierten Situation eine deutliche Verbesserung des progressionsfreien Überlebens gezeigt hatten, werden zurzeit in der adjuvanten Situation in großen Therapiestudien getestet. Diese und weitere neue Daten zur Behandlung oder Prävention des primären Mammakarzinoms werden in dieser Übersichtsarbeit vor dem Hintergrund aktueller Studien vorgestellt.

Schlüsselwörter

frühes Mammakarzinom - adjuvante Therapie - neoadjuvante Therapie - T-DM1 - Katherine - Prävention

Full Text

References

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