Bedeutung der Insulinwirkung im menschlichen Gehirn – Bertram-Preis 2019 – eine Kurzübersicht des Preisträgers Martin Heni

• Literatur

• 1 Heni M, Kullmann S, Preissl H. et al. Impaired insulin action in the human brain: causes and metabolic consequences. Nat Rev Endocrinol 2015; 11: 701-711 . doi:10.1038/nrendo.2015.173
• 2 Kullmann S, Heni M, Hallschmid M. et al. Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans. Physiol Rev 2016; 96: 1169-1209 . doi:10.1152/physrev.00032.2015
• 3 Heni M, Wagner R, Kullmann S. et al. Hypothalamic and Striatal Insulin Action Suppresses Endogenous Glucose Production and May Stimulate Glucose Uptake During Hyperinsulinemia in Lean but Not in Overweight Men. Diabetes 2017; 66: 1797-1806 . doi:10.2337/db16-1380
• 4 Schmid V, Kullmann S, Gfrörer W. et al. Safety of intranasal human insulin: a review. Diabetes Obes Metab 2018;
• 5 Kullmann S, Heni M, Veit R. et al. Selective insulin resistance in homeostatic and cognitive control brain areas in overweight and obese adults. Diabetes Care 2015; 38: 1044-1050 . doi:10.2337/dc14-2319
• 6 Kullmann S, Heni M, Hallschmid M. et al. Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans. Physiol Rev 2016; 96: 1169-1209 . doi:10.1152/physrev.00032.2015
• 7 Freiherr J, Hallschmid M, Frey WH. et al. Intranasal insulin as a treatment for Alzheimer’s disease: a review of basic research and clinical evidence. CNS Drugs 2013; 27: 505-514 . doi:10.1007/s40263-013-0076-8
• 8 Hallschmid M, Benedict C, Schultes B. et al. Intranasal insulin reduces body fat in men but not in women. Diabetes 2004; 53: 3024-3029
• 9 Tschritter O, Preissl H, Hennige AM. et al. High cerebral insulin sensitivity is associated with loss of body fat during lifestyle intervention. Diabetologia 2012; 55: 175-182 . doi:10.1007/s00125-011-2309-z
• 10 Guthoff M, Stingl KT, Tschritter O. et al. The Insulin-Mediated Modulation of Visually Evoked Magnetic Fields Is Reduced in Obese Subjects. PLoS ONE 2011; 6: e19482 . doi:10.1371/journal.pone.0019482
• 11 Flint A, Gregersen NT, Gluud LL. et al. Associations between postprandial insulin and blood glucose responses, appetite sensations and energy intake in normal weight and overweight individuals: a meta-analysis of test meal studies. Br J Nutr 2007; 98: 17-25 . doi:10.1017/S000711450768297X
• 12 Hallschmid M, Higgs S, Thienel M. et al. Postprandial administration of intranasal insulin intensifies satiety and reduces intake of palatable snacks in women. Diabetes 2012; 61: 782-789 . doi:10.2337/db11-1390
• 13 Kullmann S, Heni M, Fritsche A. et al. Insulin action in the human brain: evidence from neuroimaging studies. J Neuroendocrinol 2015; 27: 419-423 . doi:10.1111/jne.12254
• 14 Thanarajah SE, Hoffstall V, Rigoux L. et al. The role of insulin sensitivity and intranasally applied insulin on olfactory perception. Sci Rep 2019; 9: 1-8 . doi:10.1038/s41598-019-43693-7
• 15 Heni M, Wagner R, Kullmann S. et al. Central insulin administration improves whole-body insulin sensitivity via hypothalamus and parasympathetic outputs in men. Diabetes 2014; 63: 4083-4088 . doi:10.2337/db14-0477
• 16 Iwen KA, Scherer T, Heni M. et al. Intranasal insulin suppresses systemic but not subcutaneous lipolysis in healthy humans. J Clin Endocrinol Metab 2014; 99: E246-E251 . doi:10.1210/jc.2013-3169
• 17 Begg DP, Mul JD, Liu M. et al. Reversal of diet-induced obesity increases insulin transport into cerebrospinal fluid and restores sensitivity to the anorexic action of central insulin in male rats. Endocrinology 2013; 154: 1047-1054 . doi:10.1210/en.2012-1929
• 18 Yarchoan M, Arnold SE. Repurposing diabetes drugs for brain insulin resistance in Alzheimer disease. Diabetes 2014; 63: 2253-2261 . doi:10.2337/db14-0287
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