GIP ist ein Inkretinhormon, das durch westliche Ernährung verstärkt freigesetzt wird und so zu einer ungesunden metabolischen Wirkung beiträgt – Werner-Creutzfeldt-Preis 2019 – eine Kurzübersicht des Preisträgers Andreas F. H. Pfeiffer

• Literatur

• 1 Pfeiffer AFH, Keyhani-Nejad F. High Glycemic Index Metabolic Damage – a Pivotal Role of GIP and GLP-1. Trends Endocrinol Metab 2018; 29: 289-299
• 2 Nauck MA, Meier JJ. The incretin effect in healthy individuals and those with type 2 diabetes: physiology, pathophysiology, and response to therapeutic interventions. Lancet Diabetes Endocrinol 2016; 4: 525-536
• 3 Miyawaki K, Yamada Y, Ban N. et al. Inhibition of gastric inhibitory polypeptide signaling prevents obesity. Nat Med 2002; 8: 738-742
• 4 Isken F, Weickert MO, Tschöp MH. et al. Metabolic effects of diets differing in glycaemic index depend on age and endogenous glucose-dependent insulinotrophic polypeptide in mice. Diabetologia 2009; 52: 2159-2168
• 5 Rudovich NN, Rochlitz HJ, Pfeiffer AFH. Reduced hepatic insulin extraction in response to gastric inhibitory polypeptide compensates for reduced insulin secretion in normal-weight and normal glucose tolerant first-degree relatives of type 2 diabetic patients. Diabetes 2004; 53: 2359-2365
• 6 Yip RG, Wolfe MM. GIP biology and fat metabolism. Life Sci 2000; 66: 91-103
• 7 Yip RG, Boylan MO, Kieffer TJ. et al. Functional GIP receptors are present on adipocytes. Endocrinology 1998; 139: 4004-4007
• 8 Gogebakan O, Osterhoff MA, Schueler R. et al. GIP increases adipose tissue expression and blood levels of MCP-1 in humans and links high energy diets to inflammation: a randomised trial. Diabetologia 2015; 58: 1759-1768
• 9 Pivovarova O, Hornemann S, Weimer S. et al. Regulation of nutrition-associated receptors in blood monocytes of normal weight and obese humans. Peptides 2015; 65C: 12-19
• 10 Wernstedt Asterholm I, Tao C, Morley TS. et al. Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling. Cell Metab 2014; 20: 103-118
• 11 Kruse M, von Loeffelholz C, Hoffmann D. et al. Dietary rapeseed/canola-oil supplementation reduces serum lipids and liver enzymes and alters postprandial inflammatory responses in adipose tissue compared to olive-oil supplementation in obese men. Mol Nutr Food Res 2015; 59: 507-519
• 12 Spranger J, Kroke A, Möhlig M. et al. Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Diabetes 2003; 52: 812-817
• 13 Gogebakan O, Andres J, Biedasek K. et al. Glucose-dependent insulinotropic polypeptide reduces fat-specific expression and activity of 11beta-hydroxysteroid dehydrogenase type 1 and inhibits release of free fatty acids. Diabetes 2012; 61: 292-300
• 14 Masuzaki H, Paterson J, Shinyama H. et al. A transgenic model of visceral obesity and the metabolic syndrome. Science 2001; 294: 2166-2170
• 15 Rudovich N, Kaiser S, Engeli S. et al. GIP receptor mRNA expression in different fat tissue depots in postmenopausal non-diabetic women. Regul Pept 2007; 142: 138-145
• 16 Honka H, Koffert J, Kauhanen S. et al. Liver blood dynamics after bariatric surgery: the effects of mixed-meal test and incretin infusions. Endocr Connect 2018; 7: 888-896
• 17 Honka H, Koffert J, Kauhanen S. et al. Bariatric Surgery Enhances Splanchnic Vascular Responses in Patients With Type 2 Diabetes. Diabetes 2017; 66: 880-885
• 18 Asmar M, Asmar A, Simonsen L. et al. The Gluco- and Liporegulatory and Vasodilatory Effects of Glucose-Dependent Insulinotropic Polypeptide (GIP) Are Abolished by an Antagonist of the Human GIP Receptor. Diabetes 2017; 66: 2363-2371
• 19 Keyhani-Nejad F, Kemper M, Schueler R. et al. Effects of Palatinose and Sucrose Intake on Glucose Metabolism and Incretin Secretion in Subjects With Type 2 Diabetes. Diabetes Care 2016; 39: e38-e39
• 20 Keyhani-Nejad F, Irmler M, Isken F. et al. Nutritional strategy to prevent fatty liver and insulin resistance independent of obesity by reducing glucose-dependent insulinotropic polypeptide responses in mice. Diabetologia 2015; 58: 374-383