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CC BY-NC-ND 4.0 · Endosc Int Open 2019; 07(11): E1327-E1332
DOI: 10.1055/a-0957-3005
Original article
Owner and Copyright © Georg Thieme Verlag KG 2019

Does endoscopic ultrasound-guided fine needle biopsy using a Franseen needle really offer high diagnostic accuracy? A propensity-matched analysis

Akashi Fujita
1   Department of Gastroenterology, Saitama Medical University International Medical Center, Saitama, Japan
,
Shomei Ryozawa
1   Department of Gastroenterology, Saitama Medical University International Medical Center, Saitama, Japan
,
Masafumi Mizuide
1   Department of Gastroenterology, Saitama Medical University International Medical Center, Saitama, Japan
,
Ryuichiro Araki
2   Community Health Science Center, Saitama Medical University, Saitama, Japan
,
Koji Nagata
3   Department of Pathology, Saitama Medical University International Medical Center, Saitama, Japan
,
Yuki Tanisaka
1   Department of Gastroenterology, Saitama Medical University International Medical Center, Saitama, Japan
,
Maiko Harada
1   Department of Gastroenterology, Saitama Medical University International Medical Center, Saitama, Japan
,
Tomoya Ogawa
1   Department of Gastroenterology, Saitama Medical University International Medical Center, Saitama, Japan
,
Tomoaki Tashima
1   Department of Gastroenterology, Saitama Medical University International Medical Center, Saitama, Japan
,
Kouichi Nonaka
1   Department of Gastroenterology, Saitama Medical University International Medical Center, Saitama, Japan
› Author Affiliations
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Publication History

submitted 05 March 2019

accepted after revision 09 May 2019

Publication Date:
22 October 2019 (online)

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Abstract

Background and study aims This study aimed to investigate the diagnostic accuracy and utility of endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) performed using a Franseen needle on solid pancreatic lesions.

Patients and methods This study included 132 consecutive lesions sampled by endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) using a 22-G conventional needle and 95 consecutive lesions evaluated by EUS-FNB using a 22-G Franseen needle to evaluate solid pancreatic lesions at our medical center between July 2013 and November 2018. We used propensity-matched analysis with adjustment for confounders. Patient data were analyzed retrospectively.

Results Diagnostic accuracy was higher in the Franseen needle group (Group F; 91.6 %, 87 /95) than in the conventional needle group (Group C; 86.3 %, 82 /95), showing no significant difference (P = 0.36). In Group F, diagnostic accuracies for pancreatic head lesions and lesions sampled by transduodenal puncture were 98.0 % (48/49) and 97.9 % (46/47), respectively. These values were significantly higher than values in Group C (P = 0.013, 0.01). Group F displayed a significantly lower number of punctures. In terms of differentiating benign from malignant lesions, Group C showed 85.1 % sensitivity (74/87), 100 % specificity (8/8), 100 % positive predictive value (74/74), and 38.1 % negative predictive value (8/21), compared to values of 90.1 % (73/81), 100 % (14/14), 100 % (73/73), and 63.6 % (14/22), respectively, in Group F. Sensitivity and negative predictive value were better in Group F.

Conclusions Franseen needles for EUS-FNB of solid pancreatic lesions offer similar puncture performance at different lesion sites while requiring fewer punctures than conventional needles.

 

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