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DOI: 10.1055/a-0959-6057
Water assistance: also for sigmoidoscopy?
Publikationsverlauf
Publikationsdatum:
08. Januar 2020 (online)
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In this issue of Endoscopy International Open, the protocol for an ongoing randomized controlled trial (RCT) is described [1]. The primary objective is to ascertain if procedural pain, assessed post-procedure and prior to discharge, is reduced in water-assisted sigmoidoscopy (WAS) compared to carbon dioxide (CO2) insufflation in people undergoing unsedated flexible sigmoidoscopy as part of the United Kingdom Bowel Scope Screening Program (BSSP). In the BSSP, an enema is given, colonoscope used, and Entonox (nitrous oxide) readily available as needed. Recognition that water instead of gas can potentially reduce insertion pain based on published reports on water-aided colonoscopy represents an important milestone in the history of water-assisted examination of the colon. This is a well-designed trial which shows considerable promise in demonstrating a less painful method for people undergoing screening sigmoidoscopy. This editorial focuses on discussions of the timing of pain assessment and insertion technique.
Recording of pain data by a blinded research assistant immediately after examination of the colon is a sound experimental design to minimize observer bias. Pain during insertion, however, is a clinically relevant parameter as excessive insertion pain mandates discontinuation, or need to add Entonox. Therefore, real-time maximum insertion pain more accurately reflects the importance of pain reduction and is a pertinent measure to track [2] [3] [4] in addition to the current primary outcome.
Recognition of the need to reduce pain related to gas insufflation is critical to development of the protocol. The investigators should be commended for addressing the issue with this RCT using water-assisted technique. At a risk of stating the obvious, there are two main approaches to water assistance for examination of the colon, namely, water immersion (WI) and water exchange (WE) [5]. In the English-language literature, WI dates back to 1984 [6]. Water was administered into the sigmoid colon deformed by diverticulosis to facilitate passage and the infused water was removed during withdrawal. The practice is simple and easy to adopt. The approach was extended to the entire colon as WE to facilitate completion of colonoscopy in unsedated veterans in the United States. WE emphasizes removal of the infused water (and residual debris) during insertion to minimize distension and optimize reduction of real-time maximum insertion pain [2]. The serendipitous consequences of salvage cleaning during insertion and reduced multi-tasking distractions due to cleaning activities during withdrawal [7] are likely instrumental in the increase in adenoma detection when WE is used [8] [9] [10]. The key to success of WE appears to be near-complete suction removal of the infused water (along with residual debris) during insertion [11].
The WAS technique (water infusion based on endoscopist discretion, suction of infused water as needed or as per usual practice during withdrawal) [1] appears to resemble WI ([Table 1]). Data in the literature would suggest that WAS may need the addition of standardized water suction during insertion to achieve effectiveness as optimal as WE in minimizing insertion pain or increasing adenoma detection. To maximize the benefits of water assistance, it is prudent to consider use of WE for the proposed study, i. e. with near-complete suction removal of the infused water during insertion, and not just “as needed.” The history of water-aided colonoscopy showed that the change from WI to WE [3] [4] reaped important benefits of significant further reduction of insertion pain.
AI, air insufflation; CO2, carbon dioxide; RCT, randomized controlled trial; WAS, water-assisted sigmoidoscopy; WE, water exchange; WI, water immersion.
When WE is indeed adopted for flexible sigmoidoscopy, there is the potential to attempt extended flexible sigmoidoscopy [12], especially when a colonoscope is already being used in the BSSP. The only significant change is for the patient to undertake an oral bowel preparation to clean the entire colon. To the fullest extent of intubation, a WE-assisted extended flexible sigmoidoscopy is equivalent to an unsedated colonoscopy. The increased coverage of and discovery of polyps in the proximal colon without the expense and burden of sedation and return visit to remove polyps beyond the reach of the sigmoidoscope can be substantial. This would be a reasonable next step for investigators in this RCT to consider.
On a lighter note, the current RCT confirms that the investigators appreciate the disadvantages of gas insufflation for insertion. On the other hand, WE has distinct advantages. The investigators could consider trying to avoid using any insufflation at all and achieve suction salvage cleaning during insertion (should be easy now that the skills in water-assisted technique have been acquired). The full benefits of further decrease in pain and increase in adenoma detection, and possibly a greater chance to complete a higher proportion of unsedated colonoscopies than using the current technique, could be achieved. It is reasonable to experiment and have fun. Performing WE is neither boring nor excessively time-consuming in a reasonably well-prepared colon. In addition to less intense insertion pain for the patient, the annoying task of cleaning up during withdrawal can be avoided and the hunt for lesions will become more enjoyable for the colonoscopist.
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References
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- 2 Leung FW, Harker JO, Jackson G. et al. A proof-of-principle, prospective, randomized controlled trial (RCT) demonstrating improved outcomes in scheduled unsedated colonoscopy by the water method. Gastrointest Endosc 2010; 72: 693-700
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- 9 Hsieh YH, Tseng CW, Hu CT. et al. Prospective multicenter randomized controlled trial demonstrating water exchange (WE), but not water immersion (WI), significantly increases adenoma detection compared with air insufflation (AI) even in propofol sedated patients. Gastrointest Endosc 2017; 86: 192-201
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- 11 Leung FW, Jia H. Water infusion without near-complete removal during insertion by any other name is still water immersion (WI). Gastrointest Endosc 2019; 89: 599-601
- 12 Bak AW, Perini R, Schroeder T. et al. Experience with water-aided colonoscopy in a Canadian community population. Journal Interventional Gastroenterology 2013; 3: 49-52