Das kleinzellige Lungenkarzinom stellt eine besonders aggressive Tumorentität dar und ist durch schnellen Progress, sehr frühe Metastasierung und eine schlechte Prognose charakterisiert. Nur wenige Patienten werden in einem frühen Erkrankungsstadium diagnostiziert. Die systemische Therapie stellt die entscheidende Therapieform für die Mehrzahl der Patienten dar. Kürzlich konnte das systemische Therapiespektrum durch die Implementierung der Immuntherapie erstmal seit Jahrzehnten erweitert werden.
Abstract
Small cell lung cancer is an aggressive cancer entity and characterized by rapid progression, early distant metastasis and poor prognosis. Only the minority of patients presents with a non-metastatic stage disease where chemo-radiotherapy or – in very selected cases – even surgical resection may be discussed. For most patients, the efficacy of systemic therapy is crucial. However, although most patients respond to platinum doublet chemotherapy, virtually all patients with metastatic disease eventually develop tumor progression for which there are limited treatment options. Recently and for the first time since decades, the systemic approaches have been enriched by the implementation of immunotherapy. Moreover, novel therapeutic approaches such as new cytotoxic agents or further immune modulatory strategies are being tested in clinical studies that might broaden our treatment options in the future even further.
Schlüsselwörter
Lungenkrebs - Bronchialkarzinom - Chemotherapie - Strahlentherapie - Tumorresektion - Checkpointinhibitor
Keywords
pulmonary cancer - bronchial carcinoma - chemotherapy - radiation therapy - tumor resection - checkpoint inhibitor
