The Slowly Progressive, Bilaterally Simultaneous Variety of Leber Hereditary Optic Neuropathy

Background

Leber hereditary optic neuropathy (LHON) is one of the most common inherited optic neuropathies causing bilateral central vision loss. The disorder results from point mutations in mitochondrial DNA (mtDNA). The primary cell type that is lost is the retinal ganglion cell. The clinical phenotype is highly variable.

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