Update Breast Cancer 2020 Part 2 – Advanced Breast Cancer: New Treatments and Implementation of Therapies with Companion Diagnostics

Diana Lüftner; Andreas Schneeweiss; Andreas D. Hartkopf; Volkmar Müller; Achim Wöckel; Wolfgang Janni; Johannes Ettl; Erik Belleville; Florian Schütz; Marc Thill; Jens Huober; Peter A. Fasching; Hans-Christian Kolberg; Patrik Pöschke; Manfred Welslau; Friedrich Overkamp; Hans Tesch; Tanja N. Fehm; Michael P. Lux

doi:10.1055/a-1111-8775

Geburtshilfe und Frauenheilkunde, Table of Contents

CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2020; 80(04): 391-398
DOI: 10.1055/a-1111-8775

GebFra Science

Review/Übersicht

Georg Thieme Verlag KG Stuttgart · New York

Update Mammakarzinom 2020 Teil 2 – fortgeschrittenes Mammakarzinom: neue Substanzen und Einzug diagnostikabhängiger Therapien

Article in several languages: English | deutsch

Diana Lüftner

¹Charité University Hospital, Campus Benjamin Franklin, Department of Hematology, Oncology and Tumour Immunology, Berlin, Germany

,

Andreas Schneeweiss

²National Center for Tumor Diseases, Division Gynecologic Oncology, University Hospital and German Cancer Research Center, Heidelberg, Germany

,

Andreas D. Hartkopf

³Department of Obstetrics and Gynecology, University of Tübingen, Tübingen, Germany

,

Volkmar Müller

⁴Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany

,

Achim Wöckel

⁵Department of Gynecology and Obstetrics, University Hospital Würzburg, Würzburg, Germany

,

Wolfgang Janni

⁶Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany

,

Johannes Ettl

⁷Department of Obstetrics and Gynecology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany

,

Erik Belleville

⁸ClinSol GmbH & Co KG, Würzburg, Germany

,

Florian Schütz

⁹Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany

,

Marc Thill

¹⁰Agaplesion Markus Krankenhaus, Frauenklinik, Frankfurt, Germany

,

Jens Huober

⁶Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany

,

Peter A. Fasching

¹¹Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

,

Hans-Christian Kolberg

¹²Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop, Germany

,

Patrik Pöschke

¹¹Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

,

Manfred Welslau

¹³Onkologie Aschaffenburg, Aschaffenburg, Germany

,

Friedrich Overkamp

¹⁴OncoConsult Overkamp GmbH, Berlin, Germany

,

Hans Tesch

¹⁵Oncology Practice at Bethanien Hospital Frankfurt, Frankfurt, Germany

,

Tanja N. Fehm

¹⁶Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Düsseldorf, Germany

,

Michael P. Lux

¹⁷Klinik für Gynäkologie und Geburtshilfe, Frauenklinik St. Louise, Paderborn, St. Josefs-Krankenhaus, Salzkotten, Germany

› Author Affiliations

Abstract

Zusammenfassung

Für Patientinnen mit einem lokal fortgeschrittenen bzw. metastasierten Mammakarzinom wurden in den letzten Jahren neue und effektive Therapien wie CDK4/6-Inhibitoren, PARP-Inhibitoren und ein PD-L1-Inhibitor eingeführt. In dieser Übersichtsarbeit wird ein Update zu den vorhandenen Studien mit ihrer Datenlage gegeben. Ebenso werden 2 innovative Anti-HER2-Therapien dargestellt (Trastuzumab-Deruxtecan und Tucatinib), für die die Ergebnisse aus neue Studien berichtet worden sind. Molekulare Tests bieten die Möglichkeit, Patientinnenpopulationen zu definieren oder auch Therapieverläufe zu monitorieren. Dieses kann helfen, Patientinnen mit spezifischen Eigenschaften zu identifizieren, um diesen eine individuelle zielgerichtete Therapie im Rahmen von Studien zukommen zu lassen. In einer großen Studie konnte der Nutzen einer solchen Biomarkerstudie zum ersten Mal beschrieben werden.

Schlüsselwörter

fortgeschrittenes Mammakarzinom - Metastasen - Therapie - Mutationstestung - Immuntherapie - PARP - CDK4/6 - BRCA1/2 - PD-L1

Full Text

References

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