RSS-Feed abonnieren
![](/products/assets/desktop/img/oa-logo.png)
DOI: 10.1055/a-1119-6387
Cellulose nanofiber dispersion as a new submucosal injection material for endoscopic treatment: preliminary experimental study
![](https://www.thieme-connect.de/media/10.1055-s-00025476/202005/lookinside/thumbnails/1734_10-1055-a-1119-6387-1.jpg)
Abstract
Background and aims Although various solutions have been tested for submucosal injections during endoscopic treatment, the ideal solution has not been established. We investigated the suitability of a cellulose nanofiber (CNF) dispersion with high viscosity and thixotropy as a potential submucosal injection material for endoscopic treatment.
Methods We evaluated the catheter injectability and mucosa-elevating capacity of CNF dispersion compared with sodium hyaluronate (SH) solution, which has been reported to be a promising submucosal injection solution. The catheter injectability of CNF dispersion was examined under conditions equivalent to those used clinically in endoscopic treatment. The mucosa-elevating capacity of CNF dispersion was examined in porcine stomachs.
Results There was no significant difference between the catheter injectability of 0.4 % CNF dispersion and 0.4 % SH solutions; however, 0.4 % CNF dispersion maintained significantly higher and longer elevation of the submucosal layer than 0.4 % SH solution. A clear separation of the mucosal layer from the underlying muscle layer was achieved by injecting 0.4 % CNF dispersion.
Conclusion This preliminary study suggests that CNF dispersion could be an ideal submucosal injection material for endoscopic treatment because of its unique high thixotropy index.
Publikationsverlauf
Eingereicht: 03. Oktober 2019
Angenommen: 06. Januar 2020
Artikel online veröffentlicht:
17. April 2020
© 2020. Owner and Copyright ©
© Georg Thieme Verlag KG
Stuttgart · New York
-
References
- 1 Tada M, Murakami A, Karita M. et al. Endoscopic resection of early gastric cancer. Endoscopy 1993; 25: 445-450
- 2 Oka S, Tanaka S, Kaneko I. et al. Advantage of endoscopic submucosal dissection compared with EMR for early gastric cancer. Gastrointest Endosc 2006; 64: 877-883
- 3 Fujishiro M, Yahagi N, Kashimura K. et al. Comparison of various submucosal injection solutions for maintaining mucosal elevation during endoscopic mucosal resection. Endoscopy 2004; 36: 579-583
- 4 Tran RT, Palmer M, Tang SJ. et al. Injectable drug-eluting elastomeric polymer: a novel submucosal injection material. Gastrointest Endosc 2012; 75: 1092-1097
- 5 Kusano T, Etoh T, Akagi T. et al. Evaluation of 0.6% sodium alginate as a submucosal injection material in endoscopic submucosal dissection for early gastric cancer. Dig Endosc 2014; 26: 638-645
- 6 Brown EE, Hu D, Abu Lail N. et al. Potential of nanocrystalline cellulose-fibrin nanocomposites for artificial vascular graft applications. Biomacromolecules 2013; 14: 1063-1071
- 7 Nuutila K, Laukkanen A, Lindford A. et al. Inhibition of skin wound contraction by nanofibrillar cellulose hydrogel. Plast Reconstr Surg 2018; 141: 357-366
- 8 Barriga S. 2,2,6,6-Tetramethylpiperidin-1-oxyl (TEMPO). Synlett 2001; 4: 563
- 9 Isogai A, Saito T, Fukuzumi H. TEMPO-oxidized cellulose nanofibers. Nanoscale 2011; 3: 71-85
- 10 Vartiainen J, Pohler T, Sirola K. et al. Health and environmental safety aspects of friction grinding and spray drying of microfibrillated cellulose. Cellulose 2011; 18: 775-786