Chirurgie bei gutartigen soliden Lebertumoren

Maximilian Stanley Jusufi; Victoria Susanne Antonia Habbel; Karl J. Oldhafer

doi:10.1055/a-1144-6487

Allgemein- und Viszeralchirurgie up2date, Inhaltsverzeichnis

Allgemein- und Viszeralchirurgie up2date 2021; 15(01): 19-33
DOI: 10.1055/a-1144-6487

Leber, Galle, Pankreas, Milz

Chirurgie bei gutartigen soliden Lebertumoren

Maximilian Stanley Jusufi‡

,

Victoria Susanne Antonia Habbel‡

,

Karl J. Oldhafer

Abstract

Alle Artikel dieser Rubrik

Diese Übersicht konzentriert sich auf die drei häufigsten gutartigen Lebertumoren – hepatische Hämangiome, fokale noduläre Hyperplasien und hepatozelluläre Adenome – und bietet einen Überblick über die klinischen Präsentationen, das diagnostische Vorgehen, das konservative Management sowie die interventionelle und chirurgische Behandlung.

Schlüsselwörter

Benigne Lebertumoren - Leberhämangiom - fokale noduläre Hyperplasie - Leberadenom

Volltext

Referenzen

Literatur
1 de Knegt RJ, Potthoff A, Wirth T. Management benigner Lebertumoren. Internist 2020; 61: 140-146 doi:10.1007/s00108-019-00736-5
2 European Association for the Study of the Liver. EASL Clinical Practice Guidelines on the management of benign liver tumours. J Hepatol 2016; 65: 386-398 doi:10.1016/j.jhep.2016.04.001
3 Marrero JA, Ahn J, Rajender Reddy K. et al. ACG clinical guideline: the diagnosis and management of focal liver lesions. Am J Gastroenterol 2014; 109: 1328-1347 quiz 1348 doi:10.1038/ajg.2014.213
4 Buetow PC, Pantongrag-Brown L, Buck JL. et al. Focal nodular hyperplasia of the liver: radiologic-pathologic correlation. Radiographics 1996; 16: 369-388 doi:10.1148/radiographics.16.2.8966294
5 Vilgrain V, Flejou JF, Arrive L. et al. Focal nodular hyperplasia of the liver: MR imaging and pathologic correlation in 37 patients. Radiology 1992; 184: 699-703 doi:10.1148/radiology.184.3.1509052
6 Brancatelli G, Federle MP, Grazioli L. et al. Focal nodular hyperplasia: CT findings with emphasis on multiphasic helical CT in 78 patients. Radiology 2001; 219: 61-68 doi:10.1148/radiology.219.1.r01ap0361
7 Dietrich CF, Schuessler G, Trojan J. et al. Differentiation of focal nodular hyperplasia and hepatocellular adenoma by contrast-enhanced ultrasound. Br J Radiol 2005; 78: 704-707 doi:10.1259/bjr/88181612
8 Kim MJ, Lim HK, Kim SH. et al. Evaluation of hepatic focal nodular hyperplasia with contrast-enhanced gray scale harmonic sonography: initial experience. J Ultrasound Med 2004; 23: 297-305 doi:10.7863/jum.2004.23.2.297
9 Stark DD, Felder RC, Wittenberg J. et al. Magnetic resonance imaging of cavernous hemangioma of the liver: tissue-specific characterization. AJR Am J Roentgenol 1985; 145: 213-222 doi:10.2214/ajr.145.2.213
10 Kehagias D, Moulopoulos L, Antoniou A. et al. Focal nodular hyperplasia: imaging findings. Eur Radiol 2001; 11: 202-212 doi:10.1007/s003300000575
11 Mortele KJ, Praet M, Van Vlierberghe H. et al. CT and MR imaging findings in focal nodular hyperplasia of the liver: radiologic-pathologic correlation. AJR Am J Roentgenol 2000; 175: 687-692 doi:10.2214/ajr.175.3.1750687
12 Laumonier H, Bioulac-Sage P, Laurent C. et al. Hepatocellular adenomas: magnetic resonance imaging features as a function of molecular pathological classification. Hepatology 2008; 48: 808-818 doi:10.1002/hep.22417
13 Ronot M, Bahrami S, Calderaro J. et al. Hepatocellular adenomas: accuracy of magnetic resonance imaging and liver biopsy in subtype classification. Hepatology 2011; 53: 1182-1191 doi:10.1002/hep.24147
14 Toro A, Mahfouz AE, Ardiri A. et al. What is changing in indications and treatment of hepatic hemangiomas. A review. Ann Hepatol 2014; 13: 327-339
15 Glinkova V, Shevah O, Boaz M. et al. Hepatic haemangiomas: possible association with female sex hormones. Gut 2004; 53: 1352-1355 doi:10.1136/gut.2003.038646
16 Ozakyol A, Kebapci M. Enhanced growth of hepatic hemangiomatosis in two adults after postmenopausal estrogen replacement therapy. Tohoku J Exp Med 2006; 210: 257-261 doi:10.1620/tjem.210.257
17 Donati M, Stavrou GA, Donati A. et al. The risk of spontaneous rupture of liver hemangiomas: a critical review of the literature. J Hepatobiliary Pancreat Sci 2011; 18: 797-805 doi:10.1007/s00534-011-0420-7
18 Kasabach HH, Merritt KK. Capillary hemangioma with extensive purpura: report of a case. Am J Dis Child 1940; 59: 1063-1070 doi:10.1001/archpedi.1940.01990160135009
19 Srivastava DN, Gandhi D, Seith A. et al. Transcatheter arterial embolization in the treatment of symptomatic cavernous hemangiomas of the liver: a prospective study. Abdom Imag 2001; 26: 510-514 doi:10.1007/s00261-001-0007-x
20 Furumaya A, van Rosmalen BV, Takkenberg RB. et al. Transarterial (Chemo-)Embolization and Lipiodolization for Hepatic Haemangioma. Cardiovasc Intervent Radiol 2019; 42: 800-811 doi:10.1007/s00270-019-02169-x
21 Hoffmann K, Schemmer P. Benigne solide Tumoren der Leber. Allgemein- und Viszeralchirurgie up2date 2011; 5: 135-146 doi:10.1055/s-0030-1270890
22 Rubin RA, Mitchell DG. Evaluation of the solid hepatic mass. Med Clin North Am 1996; 80: 907-928 doi:10.1016/s0025-7125(05)70473-9
23 Sempoux C, Paradis V, Komuta M. et al. Hepatocellular nodules expressing markers of hepatocellular adenomas in Budd-Chiari syndrome and other rare hepatic vascular disorders. J Hepatol 2015; 63: 1173-1180 doi:10.1016/j.jhep.2015.06.017
24 Bioulac-Sage P, Cubel G, Balabaud C. et al. Revisiting the pathology of resected benign hepatocellular nodules using new immunohistochemical markers. Sem Liver Dis 2011; 31: 91-103 doi:10.1055/s-0031-1272837
25 Roche V, Pigneur F, Tselikas L. et al. Differentiation of focal nodular hyperplasia from hepatocellular adenomas with low-mechanical-index contrast-enhanced sonography (CEUS): effect of size on diagnostic confidence. Eur Radiol 2015; 25: 186-195 doi:10.1007/s00330-014-3363-y
26 Bertin C, Egels S, Wagner M. et al. Contrast-enhanced ultrasound of focal nodular hyperplasia: a matter of size. Eur Radiol 2014; 24: 2561-2571 doi:10.1007/s00330-014-3280-0
27 Ramirez-Fuentes C, Marti-Bonmati L, Torregrosa A. et al. Variations in the size of focal nodular hyperplasia on magnetic resonance imaging. Radiologia 2013; 55: 499-504 doi:10.1016/j.rx.2011.12.008
28 Rifai K, Mix H, Krusche S. et al. No evidence of substantial growth progression or complications of large focal nodular hyperplasia during pregnancy. Scand J Gastroenterol 2013; 48: 88-92 doi:10.3109/00365521.2012.737361
29 Baum JK, Bookstein JJ, Holtz F. et al. Possible association between benign hepatomas and oral contraceptives. Lancet 1973; 2: 926-929 doi:10.1016/s0140-6736(73)92594-4
30 Ribeiro A, Burgart LJ, Nagorney DM. et al. Management of liver adenomatosis: results with a conservative surgical approach. Liver Transplant Surg 1998; 4: 388-398 doi:10.1002/lt.500040505
31 Rooks JB, Ory HW, Ishak KG. et al. Epidemiology of hepatocellular adenoma. The role of oral contraceptive use. JAMA 1979; 242: 644-648
32 Steinbrecher UP, Lisbona R, Huang SN. et al. Complete regression of hepatocellular adenoma after withdrawal of oral contraceptives. Digest Dis Sci 1981; 26: 1045-1050 doi:10.1007/BF01314771
33 Martin NM, Abu Dayyeh BK, Chung RT. Anabolic steroid abuse causing recurrent hepatic adenomas and hemorrhage. World J Gastroenterol 2008; 14: 4573-4575 doi:10.3748/wjg.14.4573
34 Bunchorntavakul C, Bahirwani R, Drazek D. et al. Clinical features and natural history of hepatocellular adenomas: the impact of obesity. Aliment Pharmacol Ther 2011; 34: 664-674 doi:10.1111/j.1365-2036.2011.04772.x
35 Nault JC, Paradis V, Cherqui D. et al. Molecular classification of hepatocellular adenoma in clinical practice. J Hepatol 2017; 67: 1074-1083 doi:10.1016/j.jhep.2017.07.009
36 Dokmak S, Paradis V, Vilgrain V. et al. A single-center surgical experience of 122 patients with single and multiple hepatocellular adenomas. Gastroenterology 2009; 137: 1698-1705 doi:10.1053/j.gastro.2009.07.061
37 Pilati C, Letouze E, Nault JC. et al. Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformation. Cancer Cell 2014; 25: 428-441 doi:10.1016/j.ccr.2014.03.005
38 Zheng J, Sadot E, Vigidal JA. et al. Characterization of hepatocellular adenoma and carcinoma using microRNA profiling and targeted gene sequencing. PLoS One 2018; 13: e0200776 doi:10.1371/journal.pone.0200776
39 Bajenaru N, Balaban V, Savulescu F. et al. Hepatic hemangioma-review. J Med Life 2015; 8 Spec Issue: 4-11
40 Weimann A, Ringe B, Klempnauer J. et al. Benign liver tumors: differential diagnosis and indications for surgery. World J Surg 1997; 21: 983-990 discussion 990-981 doi:10.1007/s002689900337
41 Vogl TJ, Own A, Hammerstingl R. et al. Transarterial embolization as a therapeutic option for focal nodular hyperplasia in four patients. Eur Radiol 2006; 16: 670-675 doi:10.1007/s00330-005-2885-8
42 van Rosmalen BV, de Graeff JJ, van der Poel MJ. et al. Impact of open and minimally invasive resection of symptomatic solid benign liver tumours on symptoms and quality of life: a systematic review. HPB (Oxford) 2019; 21: 1119-1130 doi:10.1016/j.hpb.2019.02.022
43 Agrawal S, Agarwal S, Arnason T. et al. Management of Hepatocellular Adenoma: Recent Advances. Clin Gastroenterol Hepatol 2015; 13: 1221-1230 doi:10.1016/j.cgh.2014.05.023
44 Di Sandro S, Slim AO, Lauterio A. et al. Liver adenomatosis: a rare indication for living donor liver transplantation. Transplant Proc 2009; 41: 1375-1377 doi:10.1016/j.transproceed.2009.03.021
45 Chiche L, David A, Adam R. et al. Liver transplantation for adenomatosis: European experience. Liver Transplant 2016; 22: 516-526 doi:10.1002/lt.24417
46 Prodromidou A, Machairas N, Garoufalia Z. et al. Liver Transplantation for giant hepatic hemangioma: a systematic review. Transplant Proc 2019; 51: 440-442 doi:10.1016/j.transproceed.2019.01.018