Download PDF
Aktuelle Rheumatologie 2020; 45(06): 531-534
DOI: 10.1055/a-1201-2407
Übersichtsarbeit

Rheumatologische paraneoplastische Syndrome

Rheumatic Paraneoplastic Syndromes
Johannes Knitza
1   Medizinische Klinik 3 – Rheumatologie und Immunologie, Universitätsklinikum Erlangen, Erlangen
,
Georg Schett
1   Medizinische Klinik 3 – Rheumatologie und Immunologie, Universitätsklinikum Erlangen, Erlangen
,
Bernhard Manger
1   Medizinische Klinik 3 – Rheumatologie und Immunologie, Universitätsklinikum Erlangen, Erlangen
› Author Affiliations
› Further Information
Also available at
   Permissions and Reprints

Zusammenfassung

Rheumatologische paraneoplastische Syndrome sind selten, stellten jedoch eine wichtige Differenzialdiagnose zu klassischen rheumatologischen Krankheitsbildern dar. Durch das Erkennen der eindrücklichen Syndrome mit typischen Labor- und Untersuchungsbefunden ist oftmals eine beschleunigte Diagnose der zugrundeliegenden Malignität und kurative Therapie möglich. In dieser Übersichtsarbeit werden die Charakteristika rheumatologischer paraneoplastischer Syndrome vorgestellt.

Abstract

Paraneoplastic syndromes in Rheumatology are rare, but they represent an important differential diagnosis to classic rheumatic and musculoskeletal diseases. The recognition of their typical laboratory and clinical examination findings often allows an accelerated diagnosis of the underlying malignancy and curative therapy. This review presents the characteristics of paraneoplastic syndromes in rheumatology

Schlüsselwörter

Malignom - Rheumatologie - Paraneoplasie - Myositis - Tumorsuche

Key words

Malignancy - Rheumatology - Paraneoplasia - Myositis - Tumorsuche


Publication History

Article published online:
15 July 2020

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • Literatur

  • 1 Albayda J, Pinal-Fernandez I, Huang W. et al. Antinuclear Matrix Protein 2 Autoantibodies and Edema, Muscle Disease, and Malignancy Risk in Dermatomyositis Patients. Arthritis care & research 2017; 69: 1771-1776
    CrossrefPubMedSearch in Google Scholar
  • 2 Baijens LWJ, Manni JJ. Paraneoplastic syndromes in patients with primary malignancies of the head and neck. Four cases and a review of the literature. European Archives of Oto-Rhino-Laryngology and Head & Neck 2006; 263: 32-36
    CrossrefPubMedSearch in Google Scholar
  • 3 Cohen JD, Li L, Wang Y. et al. Detection and localization of surgically resectable cancers with a multi-analyte blood test. Science 2018; 359: 926
    CrossrefPubMedSearch in Google Scholar
  • 4 De Hollanda A, Beucher A, Henrion D. et al. Systemic and immune manifestations in myelodysplasia: A multicenter retrospective study. Arthritis care & research 2011; 63: 1188-1194
    CrossrefPubMedSearch in Google Scholar
  • 5 Dutton K, Soden M. Malignancy screening in autoimmune myositis among Australian rheumatologists. Internal Medicine Journal 2017; 47: 1367-1375
    CrossrefPubMedSearch in Google Scholar
  • 6 Ehrenstein B, Pongratz G, Fleck M. et al. The ability of rheumatologists blinded to prior workup to diagnose rheumatoid arthritis only by clinical assessment: a cross-sectional study. Rheumatology (Oxford) 2018; 57: 1592-1601
    CrossrefPubMedSearch in Google Scholar
  • 7 Fain O, Hamidou M, Cacoub P. et al. Vasculitides associated with malignancies: Analysis of sixty patients. Arthritis care & research 2007; 57: 1473-1480
    CrossrefPubMedSearch in Google Scholar
  • 8 Greer JM, Longley S, Edwards NL. et al. Vasculitis associated with malignancy. Experience with 13 patients and literature review. Medicine (Baltimore) 1988; 67: 220-230
    CrossrefPubMedSearch in Google Scholar
  • 9 Hautmann AH, Hautmann MG, Kölbl O. et al. Tumor-Induced Osteomalacia: an Up-to-Date Review. Curr Rheumatol Rep 2015; 17: 37
    CrossrefPubMedSearch in Google Scholar
  • 10 Irving G, Neves AL, Dambha-Miller H. et al. International variations in primary care physician consultation time: a systematic review of 67 countries. BMJ Open 2017; 7: e017902
    CrossrefPubMedSearch in Google Scholar
  • 11 Izumi M, Takayama K, Yabuuchi H. et al. Incidence of hypertrophic pulmonary osteoarthropathy associated with primary lung cancer. Respirology 2010; 15: 809-812
    CrossrefPubMedSearch in Google Scholar
  • 12 Jiang Y, Xia W-B, Xing X-P. et al. Tumor-induced osteomalacia: An important cause of adult-onset hypophosphatemic osteomalacia in China: Report of 39 cases and review of the literature. Journal of Bone and Mineral Research 2012; 27: 1967-1975
    CrossrefPubMedSearch in Google Scholar
  • 13 Kisacik B, Onat AM, Kasifoglu T. et al. Diagnostic dilemma of paraneoplastic arthritis: Case series. International Journal of Rheumatic Diseases 2014; 17: 640-645
    CrossrefPubMedSearch in Google Scholar
  • 14 Leatham H, Schadt C, Chisolm S. et al. Evidence supports blind screening for internal malignancy in dermatomyositis: Data from 2 large US dermatology cohorts. Medicine (Baltimore) 2018; 97: e9639
    CrossrefPubMedSearch in Google Scholar
  • 15 Li H, Altman RD, Yao Q. RS3PE: Clinical and Research Development. Curr Rheumatol Rep 2015; 17: 49
    CrossrefPubMedSearch in Google Scholar
  • 16 Lundberg IE, Tjärnlund A, Bottai M. et al. 2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups. Annals of the rheumatic diseases 2017; 76: 1955
    CrossrefPubMedSearch in Google Scholar
  • 17 Manger B, Lindner A, Manger K. et al. Hypertrophe Osteoarthropathie. Zeitschrift für Rheumatologie 2011; 70: 554
    CrossrefPubMedSearch in Google Scholar
  • 18 Manger B, Schett G. Palmar fasciitis and polyarthritis syndrome—Systematic literature review of 100 cases. Seminars in Arthritis and Rheumatism 2014; 44: 105-111
    CrossrefPubMedSearch in Google Scholar
  • 19 Manger B, Schett G. Paraneoplastic syndromes in rheumatology. Nature Reviews Rheumatology 2014; 10: 662-670
    CrossrefPubMedSearch in Google Scholar
  • 20 Manger B, Schett G. Rheumatic paraneoplastic syndromes – A clinical link between malignancy and autoimmunity. Clinical Immunology 2018; 186: 67-70
    CrossrefPubMedSearch in Google Scholar
  • 21 Manger B, Wacker J, Schmidt D. et al. Clinical Images: Hippokrates confirmed by positron emission tomography. Arthritis & Rheumatism 2011; 63: 1150-1150
    CrossrefPubMedSearch in Google Scholar
  • 22 Martinez-Lavin M. Exploring the Cause of the Most Ancient Clinical Sign of Medicine: Finger Clubbing. Seminars in Arthritis and Rheumatism 2007; 36: 380-385
    CrossrefPubMedSearch in Google Scholar
  • 23 Medsger TA, Dixon JA, Garwood VF. Palmar Fasciitis and Polyarthritis Associated with Ovarian Carcinoma. Annals of Internal Medicine 1982; 96: 424-431
    CrossrefPubMedSearch in Google Scholar
  • 24 Narváez J, Bianchi MM, Santo P. et al. Pancreatitis, Panniculitis, and Polyarthritis. Seminars in Arthritis and Rheumatism 2010; 39: 417-423
    CrossrefPubMedSearch in Google Scholar
  • 25 Origuchi T, Arima K, Kawashiri SY. et al. High serum matrix metalloproteinase 3 is characteristic of patients with paraneoplastic remitting seronegative symmetrical synovitis with pitting edema syndrome. Modern Rheumatology 2012; 22: 584-588
    CrossrefPubMedSearch in Google Scholar
  • 26 Podjasek JO, Wetter DA, Pittelkow MR. et al. Henoch-Schonlein purpura associated with solid-organ malignancies: three case reports and a literature review. Acta Derm Venereol 2012; 92: 388-392
    CrossrefPubMedSearch in Google Scholar
  • 27 Price S, Spencer A, Medina-Lara A. et al. Availability and use of cancer decision-support tools: a cross-sectional survey of UK primary care. British Journal of General Practice 2019; 69: e437
    CrossrefPubMedSearch in Google Scholar
  • 28 Qiang JK, Kim WB, Baibergenova A. et al. Risk of Malignancy in Dermatomyositis and Polymyositis: A Systematic Review and Meta-Analysis. Journal of Cutaneous Medicine and Surgery 2016; 21: 131-136
    CrossrefPubMedSearch in Google Scholar
  • 29 Schmalzing M. Paraneoplastische Syndrome in der Rheumatologie. Zeitschrift für Rheumatologie 2018; 77: 309-321
    CrossrefPubMedSearch in Google Scholar
  • 30 Scholtissek B, Ferring-Schmitt S, Maier J. et al. Expression of the autoantigen TRIM33/TIF1γ in skin and muscle of patients with dermatomyositis is upregulated, together with markers of cellular stress. Clinical and Experimental Dermatology 2017; 42: 659-662
    CrossrefPubMedSearch in Google Scholar
  • 31 Selva-O'callaghan A, Martinez-Gomez X, Trallero-Araguas E. et al. The diagnostic work-up of cancer-associated myositis. Curr Opin Rheumatol 2018; 30: 630-636
    CrossrefPubMedSearch in Google Scholar
  • 32 Sigurgeirsson B, Lindelöf B, Edhag O. et al. Risk of Cancer in Patients with Dermatomyositis or Polymyositis. New England Journal of Medicine 1992; 326: 363-367
    CrossrefPubMedSearch in Google Scholar
  • 33 Solans-Laqué R, Bosch-Gil JA, Pérez-Bocanegra C. et al. Paraneoplastic vasculitis in patients with solid tumors: Report of 15 cases. Journal of Rheumatology 2008; 35: 294-304
    PubMedSearch in Google Scholar
  • 34 Trallero-Araguás E, Rodrigo-Pendás JÁ, Selva-O'callaghan A. et al. Usefulness of anti-p155 autoantibody for diagnosing cancer-associated dermatomyositis: A systematic review and meta-analysis. Arthritis & Rheumatism 2012; 64: 523-532
    CrossrefPubMedSearch in Google Scholar
  • 35 Yang H, Peng Q, Yin L. et al. Identification of multiple cancer-associated myositis-specific autoantibodies in idiopathic inflammatory myopathies: a large longitudinal cohort study. Arthritis research & therapy 2017; 19: 259
    CrossrefPubMedSearch in Google Scholar
  • 36 Zundler S, Erber R, Agaimy A. et al. Pancreatic panniculitis in a patient with pancreatic-type acinar cell carcinoma of the liver – case report and review of literature. BMC Cancer 2016; 16: 130
    CrossrefPubMedSearch in Google Scholar